Instrumentation:
- Titan Krios G3 (300 keV X-FEG, ThermoFisher Scientific) cryo-TEM
- BioQuantum Energy Filter with K2 Summit direct detector (to be upgraded to BioContinuumHD Imaging Filter with K3 camera in early 2026)
- Volta Phase Plate
- 12-position cryo-sample autoloader
- Automated data collection through EPU, Tomo, and SerialEM
- BioContinuumHD Imaging Filter with K3 Camera (Gatan) — Coming Soon
- Energy-filtered direct detection for high-contrast imaging and tomography
- 94-megapixel super-resolution mode at 1502 frames per second
- EELS and EFTEM data acquisition options
- Real-time GPU-based motion correction
- TFS Glacios F30 (200 keV X-FEG, ThermoFisher Scientific) cryo-TEM
- Falcon 4i
- Selectris Energy Filter
- 12-position cryo-sample autoloader
- MicroED
- Automated data collection through EPU, Tomo, and SerialEM
- Talos Transmission Electron Microscope (TEM, ThermoFisher Scientific) — Coming Soon
- 120 kV instrument for negative stain EM and cryo-TEM
- 4K × 4K CETA CMOS camera
- Routine negative stain imaging for rapid sample screening
- Tomography and preliminary structural analysis
- SingleParticle GPU Workstation — Coming Soon
- Dual Intel Xeon processors, 1 TB ECC memory
- Four NVIDIA RTX PRO™ 6000 Blackwell GPUs (96GB each)
- Pre-installed cryo-EM software: RELION, cryoSPARC, Scipion, DeepEMhancer, and more
- Ancillary equipment for cryospecimen preparation
- FEI Vitrobot (Mark IV)
- Leica EMGP
- Manual plungers
- Glow Discharging
- Carbon Coating
Acknowledging Cryo-EM Core
Any use of the resources at UTHealth Cryo-EM Core Facility requires acknowledgement of the resources in publications and presentations.
Any work taking place on the Glacios must acknowledge the NIH S10ODO32204 grant.
Example: Cryo-EM work (or Some of this cryo-EM work) was performed at the Cryo-EM Core Facility supported by the UTHealth Structural Biology Imaging Center at Houston and by grant from the NIH Office of the Director (1S10OD032204).