AEROSOL DEPOSITION IN ANATOMICALLY REALISTIC CT SCAN BASED THREE DIMENSIONAL COMPUTER MODEL OF HUMAN LUNGS

Author: Ashish Singh, MS

Primary Advisor: Ananth Annapragada, PhD (co-author)

Committee Members: Michael Brandt, PhD; M. Sriram Iyengar, PhD

Masters thesis, The University of Texas Health Science Center School of Health Information Sciences at Houston.

 
A mathematical model to calculate airway specific deposition of particles in an anatomically real, patient specific, three dimensional model of lungs is developed, in this study. Realistic, computer based, three dimensional model of lungs proposed by Tawhai et al32 is used to obtain the particle deposition. Particle deposition is calculated by extending the mathematical model proposed by Landahl17 and later used by Gerrity11 to the patient specific lung geometry. The generated deposition is validated by simulating gamma scintigraphic images of deposition in the lungs. The images that are characteristic of different particle parameters and lung pathologies are synthesized. Basic simulations of diseased lungs affected by cystic fibrosis are also done. While simulations for healthy lungs compared well with existing studies, the diseased lung simulations indicated a need for more detailed modeling. The deposition calculations are the first of their kind to generate lung deposition to the specificity of individual airways.