Office of Research

Research Service Centers

Research Service Centers

Core Laboratories

Other Research Facilities and Services


UTHealth encourages the development of collaborative relationships among faculty around research and academic mission-related interests. To that end, UTHealth enables academic departments, schools, and the university itself to establish fee-for-service research service centers (“RSC”), core laboratories, and other research facilities and services for specific purposes in pursuit of these missions. To learn more about the policies governing the development and administration of RSCs, see Development and Administration of Research Service Centers.


To learn more about UTHealth's Research Service Centers, Core Laboratories, and Other Research Facilities and Services, make a selection from the list below or scroll down to see descriptions and contact information.

Research Service Centers

Core Laboratories

Other Research Facilities & Services

Atomic Force Microscopy Facility Cellular Therapy Core Biobank (CCTS)
Bioinformatics Service Center Clinical Research Unit (CRU) (CCTS) Center for Clinical Research & Evidence-Based Medicine
Bone Histomorphometry and Biomaterials Laboratory Electron Paramagnetic Resonance (EPR) Center for Clinical and Translational Sciences (CCTS)
Center for Laboratory Animal Medicine & Care (CLAMC) Fluorescent/Phosphorescent Imaging Core Laboratory Center for Protein Chemistry
Cytodynamic Imaging Facility MMG Core Facilities IMM CARDIA Core Facility
Electron Microscopy Magnetic Circular Dichroism/Circular (MCD/CD)
Fluorescence Microscopy & Imaging Core Laboratory Sequencing Core
Genetics Core Lab Structural Biology Imaging Center
IMM Flow Cytometry Service Center
IMM Histopathology Service Center
IMM Transgenic & Stem Cells Service Center
Electron Microscopy Facility
Medical School Histology Lab
Clinical & Translational Proteomics Service Center
UT MRI Facility
UT Pre-Clinical CT Facility
IMM Research Administrative Services
HSC Core Labs (Quantitative Genomics & Microarray Facilities Lab)
NanoChemistry Service Center
IMM Microscopy Service Center

Molecular Diagnostic (aka Proteopath Clinical Laboratory)

 


Research Service Centers

Atomic Force Microscopy Facility Flyer

Department
of Internal Medicine-Cardiology

1881 East Road
3SCRB 6.3728
Houston, Texas 77054

713.486.5418

Services include: 
  • AFM imaging combined with bright-field/fluorescence microscopy 
  • Topographical imaging of samples in air or liquid environments
  • High-resolution imaging 
  • Time-lapse experiments that show real-time changes in sample morphology or structure
  • Nano-probing of samples to measure the interaction of forces between molecules
  • Studies of local micromechanical properties of samples (elasticity, stiffness, roughness)
  • Data analysis for determination of homogeneity of samples, size distribution, position, mapping and 3D imaging.

UTHealth Bioinformatics Service Center

South Campus Research Building #3 (3SCR6.4680) 
1881 East Road
Houston, Texas 77054

713.500.3672

The UTHealth Bioinformatics Service Center provides expertise to process and analyze biological data. Center faculty focus on gene expression, genotyping, proteomics, metabonomics, and next-generation sequencing data and can also perform custom or other complex analyses. Additional services available include experiment design and assistance in developing grant applications and manuscripts.

Bone Histomorphometry and Biomaterials Laboratory

Center for Laboratory Animal Medicine & Care (CLAMC)Website

 

CLAMC is responsible for the health and well being of laboratory animals used for the institution's biomedical research programs. CLAMC works in tandem with the institutional Animal Welfare Committee, and it meets all standards mandated by the Animal Welfare Act, Center for Disease Control, National Research Council Guide for the Care and Use of Laboratory Animals, Association for Assessment and Accreditation of Laboratory Animal Care - International, and the Public Health Service Policy on Humane Care and Use of Laboratory Animals.

Cytodynamic Imaging Facility Website (IBP)

Department
of Integrative Biology & Pharmacology 

6431 Fannin St.
Medical School Building 4.536
Houston, TX 77030

713.500.7495

 

The Cytodynamic Imaging Facility is a state of the art microscopy facility which directly supports the Department of Integrative Biology and Pharmacology. The facility is available for use by scientists within UTHealth and the Texas Medical Center. Available equipment includes:

Electron Microscopy Website

Department
of Pathology & Laboratory Medicine

6431 Fannin, MSB 2.430
Houston, TX 77030

713.500.5281

Through the use of highly specialized instrumentation, the lab provides essential diagnostic interpretation of renal, neurological, and surgical specimens to patients in the Texas Medical Center and surrounding areas.

The laboratory uses high resolution electron cryomicroscopy to explore the biology of alphavirus replication including assembly and the host-virus interactions that are necessary for infection.

Fluorescence Microscopy and Imaging Core Laboratory

Department 
of Pathology & Laboratory Medicine

6431 Fannin, MSB 2.221L
Houston, TX 77030

713.500.5260

 

The Fluorescence Microscopy and Imaging Core Laboratory is a multi-user facility whose purpose is to allow research scientists access to state of the art Fluorescence Microscopes and Imaging equipment, to foster experimentation for the further understanding of scientific phenomena in many diverse areas of clinical and basic research. The lab houses 4 Wide-Field inverted Epi-Fluorescence Microscopes and features a DeltaVision Deconvolution Microscopy System (Applied Precision Inc.) for 3-D rendering of up to 5 separate targets (Wavelengths/Probes) simultaneously, with subsequent Quantitative Image Analysis (SoftWoRx® Imaging Software), volume rotations (Exported as MPEG or AVI Files) and computer generated models. The Facility also features a Live-Cell Imaging System (PCI®) capable of capturing 3 wavelengths (probes) simultaneously, together with high speed image acquisition (up to 1000 frames per second) of single wavelength probes and/or multi-wavelength probes (Ratio of Dual Emission) for measuring ionic concentrations such as Calcium, Magnesium, Potassium concentrations and pH. Various environmental chambers are available for long-term fluorescence studies in such environments as hypoxia, hyperthermia and cold temperatures. Other imaging capabilities include Bright-Field Microscopy (Color and Grayscale), simultaneous fluorescence and Bright-Field image acquisition and standard Histology slide scanning.

Genetics Core Lab Overview

6431 Fannin St.
MSB 6.100
Houston, TX 77030

713.500.6715

The Genetic Core Laboratory, CCTS, provides consultative expertise, mentoring, and technical support for studies, while employing genetic technologies, including DNA sequencing, genotyping techniques, data collection, and statistical analyses.  The DNA Sequencing and Genotyping Core Laboratory Program is composed of four major components:

  • Consultative and mentor-based support services that provide individual investigators with guidance in the design, application, and interpretation of their genetic studies
  • Expertise in issues relating to proper informed consent for genetic studies and genetic counseling for patients enrolled in the studies.
  • Sanger DNA sequencing and microsatellite and SNP genotyping services that generate preliminary data supporting translational genetic research studies.
  • Infrastructure for banking DNA and other samples from patient populations and management system for sample tracking.

IMM Flow Cytometry
Service Center


1825 Pressler Street
SRB R617
Houston, TX 77030

713.500.3612

The Flow Cytometry Service Laboratory is located at IMM-Molecular Imaging Center and operates three instruments: a BD FACSAria II Special Order Research Product, a BD FACSCalibur and a Luminex LX200. All instruments are available to off-site users on a fee for service basis. Training is also readily available. The BD FACSAriaII SORP is a state-of-the-art 19 parameter instrument equipped with six fiber-optic-linked solid-state lasers, a 355nm UV laser, a 488nm Blue laser, a 561nm Yellow-Green laser, a 640nm Red laser, a 405nm Violet laser, and a highly specialized 785nm Near-InfraRed laser, capable of detecting up to 17 fluorescent signals and simultaneous aseptic sorting of up to four rare cell populations. The BD FACSCalibur provides user-friendly multicolor analysis capabilities and is capable of detecting up to four fluorescent signals. The Luminex system enables the multiplex of up to 100 analytes in a single microplate well.

IMM Histopathology
Service Center Website

1825 Pressler Street

SRB 637B

Houston, TX 77030

713.500.3386

 

The Brown Foundation Institute of Molecular Medicine (IMM) is now providing in-house routine histology, special stain, and immunohistochemistry services in support of research projects. With the growth of research activities the laboratory houses equipment for the preparation of thin sections; both paraffin and fresh frozen-tissue.

A full range of histopathology services include:

  • Routine Histology(Process, Embed, cut and stain)
  • Section cut rolled and placed in microcentrifuge tub for DNA, RNA studies
  • Multi-Tissue Embedding & Sectioning
  • Frozen tissue Embedding & Sectioning
  • Blood Smear stain
  • Immunohistochemistry and Special stain

IMM Transgenic and Stem Cells Service Center

1825 Pressler Street

 

SRB 637B

Houston, TX 77030

713.500.2542

The Transgenic and Stem Cells Core Facility was established in 1998 and since that time, it has generated over 650 new transgenic and knock-out mouse animal models for investigators from UTHealth, as well as for scientists from numerous other academic institutions.

The stem cell lines that have been derived in the laboratory are highly effective for the generation of knock-out/ knock-in mice and for cell differentiation studies. In addition to the production, cryopreservation and re-derivation of genetically-engineered mice and rats, the services of the facility also include gene targeting, derivation of new cell lines and intellectual/technical support in different aspects of microsurgery, cell culture and stem cells research.

Electron Microscopy Facility Website

Department of Neurobiology
& Anatomy

6431 Fannin
MSB 7.404
Houston, TX 77030

713.500.5617

 

The Electron Microscopy Facility provides investigators with modern resources for analyzing neuronal ultrastructure and macromolecular structure. There are five components of the facility:

  • Tissue Preparation and Embedding
  • Tissue Sectioning
  • Light Microscopy
  • Electron Microscopy
  • Photographic Darkroom

Most users will fix and embed tissues in their own laboratories. There is, however, limited space in the facility for tissue preparation and embedding, including a hood and oven. There are several microtomes for preparing sections from plastic embedded tissue: a sliding microtome (Microm Model HM 400) for preparing thick sections and three ultra-microtomes for preparing thin sections (Sorvall, Reichert and Reichert Ultracut for serial sectioning). A carbon coater is used to stabilize thin sections. Thick tissue sections are examined on two light microscopes (Zeiss Photomicroskop III and Zeiss Standard with camera lucida). Thin sections are examined on the JEOL 100CX electron microscope. The facility has two darkrooms, one for EM negative development, the other for photographic printing. The printing darkroom is equipped with a Beseler enlarger, automatic print processor and flat bed dryer. There is also a Kreonite sink for manual processing of prints. Use of facility requires payment of an annual maintenance fee, which varies from year to year. An initial consultation is available at no charge. The EM facility is staff by a technician who will be available to assist on a limited basis in the preparation of specimens and the operation of the electron microscope.

Medical School Histology Lab Website

Department of Pathology
& Laboratory Medicine

6431 Fannin
MSB 611
Houston, TX 77030

713.500.6792

The Histology Labs at UTHealth Dept. of Pathology & Laboratory Medicine provide a full range of histopathologic services, including

  • Trimming, decalcification, processing and embedding of tissue samples
  • Both paraffin and frozen sectioning capabilities
  • A wide variety of routine and specialized stains
  • State of the art immunohistochemistry and immunofluorescent staining
  • Image analysis equipment and services
  • High quality results and rapid turnaround time

Clinical & Translational Proteomics Service Center

1825 Pressler Street
Houston, TX 77030

713.500.4556

 

The Clinical and Translational Proteomics Service Center provides state-of-the-art instrumentation and services to the entire UTHealth and surrounding research community. Our center offers both routine services for faculty who cannot afford nor desire the purchase of their own mass spectrometry instrumentation and collaborative research requiring advanced methods.  The center works in a collaborative fashion between faculty, students and staff to customize services to suit individual projects.

The state –of –art instrumentation:

  • Thermo LTQ Orbitrap XL-ETD mass spectrometer
  • Agilent's 6538 Ultra High Definition Accurate-mass Q-TOF
  • Agilent's 6430 Triple Quadrupole LC/ MS
  • Applied Biosystems/MDS SCIEX QSTAR Elite Mass Spectrometer

 A full range of the services:

  • Protein identification from 1D gel bands, 2-D spots and other matrices
  • Molecular weight determination, peptide and protein QC
  • Targeted Proteomics (SRM) for biomarker discovery as well as quantitation of selected proteins or peptides in a complex mixture
  • Biomarker discovery and verification
  • Pharmaceutical protein QA & QC 
  • Characterization of immunoprecipitated or affinity-purified proteins and protein complexes
  • Global protein profiling with quantitative comparisons between samples (Label free, iTRAQ, SILAC etc)
  • Enrichment and characterization of post-translationally modified proteins and peptides

UT MRI Facility Website

6431 Fannin

MSB 

G.604 and G.605 

 

 

 

Houston, TX 77030

713.500.7684

The main emphasis of the MR research group at the University of Texas Medical School at Houston is the development and application of advanced magnetic resonance imaging (MRI) techniques, including selective tissue imaging, magnetic resonance spectroscopic imaging, diffusion tensor imaging to neurological disorders, central nervous system trauma, and drug addiction both in humans and animal models.

Another major emphasis of our research is the development of novel image processing techniques that are robust and automatic for handling large number of images that are typically encountered in multi-center clinical trials.

The laboratory facilities include a 7 Tesla, state-of-the-art MRI scanner dedicated to animal studies with a fully equipped animal surgical suite, a research dedicated 3 Tesla whole body scanner, and an image processing laboratory with a high performance computing cluster and GPU processing.

UT Pre-Clinical CT Facility

6431 Fannin
MSB 5.302 
Houston, TX 77030

713.500.5582

The Preclinical CT is a core lab within The University of Texas Medical School at Houston, featuring a rare CT system specialized for rapid high resolution imaging of objects up to size of large rabbits. The facility utilizes the The GE eXplore Ultra which provides high-quality images with contrast to-noise, resolution and dose performance optimized for pre-clinical imaging. As a non-profit service provider, costs are relatively low at $275/hr; with the system’s high throughput, the per-scan cost is often less than $25. Pricing for non-academic groups is $550/hr.

IMM Research Administrative Services

1825 Pressler Street
Houston, TX 77030

713.500.7547

 

Quantitative Genomics and Microarray Facilities Lab

The Quantitative Genomics & Microarray Service Center provides investigators access to state-of-the-art detection technologies, automation and expertise for a variety of scientific methodologies. The facility can perform all techniques associated with a qPCR instrument, quantitative Meso Scale ELISAs and microarrays utilizing Illumina and Agilent arrays.
NanoChemistry Service Center The Nano Chemistry Service Center provides custom synthesis, labeling, and chemical coupling of DNA thioaptamers and nanoparticles. The Director and Lab Manager are both Ph.D. chemists with years of experience in DNA synthesis, especially the more difficult monothioated and dithioated DNA. In addition, they have conjugated numerous dyes, chelators, chemical linkers, and DNA spacers onto DNA. They have conjugated such DNA aptamers to liposomes, gold nanoparticles and mesoporous silicon particles for multi-stage vectors.
IMM Micropscopy Service Center

The IMM Microscopy Service Center provides confocal microscopy, widefield fluorescence microscopy, and image analysis services to UTHealth as well as external customers.

The facility is equipped with an upright Leica TSC SP5 confocal microscope, a Nikon Eclipse TE2000E inverted widefield microscope, and a dedicated computer workstation running the latest version of Amira software for advanced visualization and analysis of imaging data. Training is available for users who would like to operate our equipment on their own. The facility manager can also perform the imaging or the analysis for you, so just send in the specimen or the raw data. Let us know how we can be of help to you.

Molecular Diagnostic (aka Proteopath Clinical Laboratory)

Proteopath Clinical Laboratory is a CLIA certified clinical laboratory now offering Vitamin D as well as TDM (Therapeutic Drug Monitoring) assays.  A product of the University of Texas Health Science Center, Proteopath adheres to the mission and vision of UTHSC by using GLP and CLIA certification to insure that your patient as well as your research receives the highest quality processes a laboratory can provide.  Whether you care for patients or you are involved in pre-clinical or clinical trials,increasing FDA guidance for labeling in vitro diagnostic devices requiring clinical validation or clinical trials has created a need for more CLIA certified laboratories.

Proteopath has anticipated the need for a CLIA certified laboratory with experience in clinical as well as research testing required to support clinical, diagnostic and R & D projects.


Core Laboratories

Cellular Therapy Core

Fabio Triolo, Ph.D., Director

phone: (713) 486-2542       fax: (713) 486-2522

e-mail: Fabio.Triolo@uth.tmc.edu

The Cellular Therapy Core (CTC) consists of the Judith R. Hoffberger Cellular Therapeutics Laboratory and the Evelyn H. Griffin Stem Cell Therapeutics Research Laboratory. The Hoffberger laboratory is located on the 6th floor of the Medical School Building and is focused on translating, scaling-up, validating and supporting IND applications (CMC section) of promising new therapeutic technologies developed by scientists and physicians at a preclinical level into clinical-grade processes that can be used to manufacture cell-based and/or tissue engineered products for clinical applications. The Griffin Laboratory is located on the 6th floor of the Behavioral and Biomedical Sciences Building and is an FDA-registered facility where tissues and organs are processed to produce cells for clinical applications in compliance with current Good Manufacturing Practice (cGMP).

Among services provided by the CTC are:
• Early involvement of experts in regulatory issues and process development
• Development and/or translation, optimization, scale-up and validation of manufacturing processes
• Development and writing of Standard Operating Procedures (SOPs)
• Development and validation of protocol-specific quality control (QC) assays
• Support of IND applications (CMC section)
• cGMP-compliant manufacturing of clinical-grade cell and/or tissue engineering products

Please contact us to discuss your specific needs.

Clinical Research Units Website
(CCTS) Website

Houston: 713.500.7928

The mission of the CCTS CRU is to facilitate clinical research by providing investigators with specialized facilities, personnel, and advice. 

Electron Paramagnetic Resonance (EPR)

 

Fluorescent/Phosphorescent Imaging Core Laboratory Website

Department of Neurobiology & Anatomy

6431 Fannin
MSB 7.438
Houston, TX 77030

713.500.5621

 

The Department maintains a GE Healthcare Typhoon Trio+ flat bed imaging system originally acquired through an equipment grant funded in 2010 by the NIH/NCRR (S10 RR027359). The Trio+ is a state-of-the-art imaging system that can scan a variety of sample types from 1000 to 10 µm resolution. The typical use of this type of instrument is for quantitative analysis of Western blots, tissue sections, or other relatively flat samples. The system has three lasers capable of simultaneously exciting three different fluorescent dyes.  Western blots or tissue sections can be stained with multiple antibody/fluorescent dye combinations so within sample analyses can be compared directly. Data analysis is accomplished through the IQTL suite of software modules.

In addition, the equipment grant funded the purchase of the DeCyder 2.0 software and an accompanying workstation.  The DeCyder software automates the analysis of 2D-DIGE (difference in gel electrophoresis) data that has become the standard for high-resolution comparative analysis of protein samples using 2D IEF/SDS-PAG electrophoresis.

MMG Core Facilities

Department of Microbiology
& Molecular Genetics

6431 Fannin
MSB 1.208
Houston, TX 77030

713.500.5467

 

The MMG Core Facility provides a variety of services for researchers within UTHealth as well as other academic institutions. The equipment available for use includes the following:

  • a JEOL JEM-1400, a 120 keV cryo-transmission electron microscope with electron tomography capabilities.
  • a Biacore 2000 instrument, which employs state-of-the-art surface plasmon resonance technology and microfluidics for the real-time analysis of macromolecular interactions.
  • a ABI 7500 Real Time PCR System (96 well plate). Real time PCR is available at $25 per run. This price includes only the run. Reagents and consumables are not included in this price.

Magnetic Circular Dichroism/Circular (MCD/CD)

 

Sequencing Core Website

1825 Pressler Street
Houston, TX 77030

713.500.9803

 

An automated DNA sequencing core facility is accessible to all investigators. Protocols designed to make the core proficient in high through-put DNA sequencing have been implemented and the complete spectrum of DNA variation can be made available. Analytical methods have been developed so that analyses of these variant DNA sites may proceed in a logical manner. Finally, the staff of the core facility are developing novel experimental protocols to provide the most accurate data for analysis of DNA sequences necessary for the use of molecular biology techniques.

Structural Biology Imaging Center Website

6431 Fannin
MSB 6.218
Houston, TX 77030

713.500.5416

 

The Structural Biology Imaging Center is dedicated to facilitation of structural biology research activities on structure/function of macromolecular and subcellular complexes using key structural techniques: nuclear magnetic resonance (NMR), X-ray crystallography, and electron microscopy (EM). The Center supports and coordinates maintenance of the equipment used in structural biology research and provides services to the users, including data collection and training.

The Center provides access to 600 MHz NMR facility, Tecnai Polara G2 300 kV and JEOL 1200EX 100kV cryo-electron microscopes, an X-ray diffractometer, all located within the UT at Houston Medical School, and also to the synchrotron beam line of the Molecular Biology Consortium at the University of California Berkeley for X-ray crystallography. The equipment is available to researchers from the Medical School as well as the members of greater Houston research community (on a per-fee or collaborative basis).


Other Research Facilities & Services

Biobank-(CCTS)

713.500.2047

 

The CCTS Biobank consists of human samples and related clinical data owned by contributing investigators within the Texas Medical Center. More than 14,800 samples have been distributed to 53 researchers since 2002. The CCTS Biobank is decentralized; sample inventory and data reside with the contributing principal investigators. 

The following sample types are available:

  • plasma
  • serum
  • DNA
  • buffy coat
  • The major disease categories include:

    • cardiovascular diseases
    • aneurysms
    • cancer
    • autoimmune system disorders

Center for Clinical Research Website & Evidence-Based Medicine

6431 Fannin
MSB 2.106
Houston, TX 77030

713.500.6708

 

The goal of the Center is to increase the public's healthy years of life by promoting high-quality clinical research and by advancing the application of this research in preventing illness and reducing suffering, disability, and premature death. The Center was established in July 1998. In conjunction with other programs provided by the Center for Clinical and Translational Sciences Website, Center faculty and staff offer a variety of educational programs and support services to advance clinical research endeavors and promote an environment that fosters high-quality clinical research.

Center for Clinical and Translational Sciences (CCTS)Website

6410 Fannin
UPB 1100
Houston, TX 77030

713.500.7923

 

The goal of the Center for Clinical and Translational Sciences (CCTS) is to facilitate clinical and translational research at The University of Texas Health Science Center at Houston, The University of Texas M. D. Anderson Cancer Center, and the Memorial Hermann Hospital System.  The CCTS is one of the original 12 such centers funded by the National Institutes of Health’s Clinical and Translational Science Awards (CTSAs). The CCTS is also a member of the Texas CTSA Consortium.

Center for Protein Chemistry Website

1825 Pressler Street
Houston, TX 77030

713.500.2548

 

The Center for Protein Chemistry examines the structural analysis of proteins while addressing a range of diseases, including neurodegenerative diseases.  Current and past research activities of the Center for Protein Chemistry focus on four major areas of interest:

  1. Development of sensitive methodologies for structural characterization of peptides and proteins. 
  2. Characterization of structure and function of proteins. 
  3. Elucidation of the pathway(s) of protein folding and unfolding.
  4. Production of stabilized non-native protein isomers and characterization of their biological and immunological properties.

IMM CARDIA Core Facility

1825 Pressler Street
Houston, TX 77030