Publications

2011

Takeuchi H., Fernandez-Valdivia, R., Caswell D., Nita-Lazar A., Rana N., Garner T., Weldeghiorghis T., Macnaughtan M., Jafar-Nejad H., and Haltiwanger R.S. (2011). Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase. PNAS 108, 16600-16605.

Leonardi, J.*, Fernandez-Valdivia, R.*, Li, Y, Simcox, A.A., and Jafar-Nejad, H. (2011). Multiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling. Development 138, 3569-78. *equal contribution

Fernandez-Valdivia, R., Takeuchi, H., Samarghandi, A., Lopez, M., Leonardi, J., Haltiwanger, R.S., and Jafar-Nejad, H. (2011). Regulation of the mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi. Development 138, 1925-34.

2010

Lee, T.V., Takeuchi, H., and Jafar-Nejad, H. (2010). Regulation of Notch Signaling Via O-Glucosylation: Insights from Drosophila Studies. Methods Enzymol 480C, 375-398.

Jafar-Nejad, H., Leonardi, J., and Fernandez-Valdivia, R. (2010). Role of glycans and glycosyltransferases in the regulation of Notch signaling. Glycobiology 20, 931-949.

2008

Simcox, A.A.*, Austin, C.L., Jacobsen, T.L., and Jafar-Nejad, H.* (2008). Drosophila embryonic 'fibroblasts': extending mutant analysis in vitro. Fly (Austin) 2, 306-309. *corresponding author

Lim, J., Jafar-Nejad, H., Hsu, Y.C., and Choi, K.W. (2008). Novel function of the class I bHLH protein Daughterless in the negative regulation of proneural gene expression in the Drosophila eye. EMBO Rep 9, 1128-1133.

Acar, M.*, Jafar-Nejad, H.*, Takeuchi, H.*, Rajan, A., Ibrani, D., Rana, N.A., Pan, H., Haltiwanger, R.S., and Bellen, H.J. (2008). Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Cell 132, 247-258. *equal contribution

2007

Rogaeva, A., Ou, X.M., Jafar-Nejad, H., Lemonde, S., and Albert, P.R. (2007). Differential repression by freud-1/CC2D1A at a polymorphic site in the dopamine-D2 receptor gene. J Biol Chem 282, 20897-20905.

2006

Acar, M.*, Jafar-Nejad, H.*, Giagtzoglou, N., Yallampalli, S., David, G., He, Y., Delidakis, C., and Bellen, H.J. (2006). Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator. Development 133, 1979-1989. *equal contribution

Jafar-Nejad, H., Tien, A.C., Acar, M., and Bellen, H.J. (2006). Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin. Development 133, 1683-1692.

Hamaratoglu, F., Willecke, M., Kango-Singh, M., Nolo, R., Hyun, E., Tao, C., Jafar-Nejad, H., and Halder, G. (2006). The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol 8, 27-36.

2005

Jafar-Nejad, H., Andrews, H.K., Acar, M., Bayat, V., Wirtz-Peitz, F., Mehta, S.Q., Knoblich, J.A., and Bellen, H.J. (2005). Sec15, a component of the exocyst, promotes Notch signaling during the asymmetric division of Drosophila sensory organ precursors. Dev Cell 9, 351-363.

Tsuda, H., Jafar-Nejad, H., Patel, A.J., Sun, Y., Chen, H.K., Rose, M.F., Venken, K.J., Botas, J., Orr, H.T., Bellen, H.J., and Zoghbi H.Y. (2005). The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. Cell 122, 633-644.

2004

Jafar-Nejad, H., and Bellen, H.J. (2004). Gfi/Pag-3/senseless zinc finger proteins: a unifying theme? Mol Cell Biol 24, 8803-8812.

Quan, X.J., Denayer, T., Yan, J., Jafar-Nejad, H., Philippi, A., Lichtarge, O., Vleminckx, K., and Hassan, B.A. (2004). Evolution of neural precursor selection: functional divergence of proneural proteins. Development 131, 1679-1689.

2003

Jafar-Nejad, H., Acar, M., Nolo, R., Lacin, H., Pan, H., Parkhurst, S.M., and Bellen, H.J. (2003). Senseless acts as a binary switch during sensory organ precursor selection. Genes Dev 17, 2966-2978.

Zhai, R.G., Hiesinger, P.R., Koh, T.W., Verstreken, P., Schulze, K.L., Cao, Y., Jafar-Nejad, H., Norga, K.K., Pan, H., Bayat, V., Greenbaum, M.P., and Bellen, H. J. (2003). Mapping Drosophila mutations with molecularly defined P element insertions. Proc Natl Acad Sci U S A 100, 10860-10865.

Ou, X.M., Lemonde, S., Jafar-Nejad, H., Bown, C.D., Goto, A., Rogaeva, A., and Albert, P.R. (2003). Freud-1: A neuronal calcium-regulated repressor of the 5-HT1A receptor gene. J Neurosci 23, 7415-7425.

2002

Jafar-Nejad, H., Norga, K., and Bellen, H. (2002). Numb: "Adapting" Notch for endocytosis. Dev Cell 3, 155-156.

2000

Ou, X.M., Jafar-Nejad, H., Storring, J.M., Meng, J.H., Lemonde, S., and Albert, P.R. (2000). Novel dual repressor elements for neuronal cell-specific transcription of the rat 5-HT1A receptor gene. J Biol Chem 275, 8161-8168.

· Simcox, A.A.*, Austin, C.L., Jacobsen, T.L., and Jafar-Nejad, H.* (2008). Drosophila embryonic 'fibroblasts': extending mutant analysis in vitro. Fly (Austin) 2, 306-309. *corresponding author (http://www.ncbi.nlm.nih.gov/pubmed/19077546)

· Lim, J., Jafar-Nejad, H., Hsu, Y.C., and Choi, K.W. (2008). Novel function of the class I bHLH protein Daughterless in the negative regulation of proneural gene expression in the Drosophila eye. EMBO Rep 9, 1128-1133. (http://www.ncbi.nlm.nih.gov/pubmed/18758436)