The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases

 Radbod Darabi, M.D, Ph.D.

Radbod Darabi, M.D, Ph.D.

Assistant Professor, Center for Stem Cell and Regenerative Medicine

Radbod.Darabi@uth.tmc.edu

713-500-3411

Dr. Darabi’s lab main interest is using pluripotent stem cells for skeletal muscle regeneration. During the last few years, Dr. Darabi has developed novel methods for using mouse/ human embryonic stem cells (ES cells) and induced pluripotent cells (iPS cells) for cell therapy in mouse models of muscular dystrophies.

Here at IMM, his lab focuses on the approaches to improve stem cell therapies for skeletal muscle regeneration. His research will include optimizing cell delivery, survival and engraftment, study mechanisms involved in cell homing into the muscle after systemic cell delivery, as well as exploring the effect of local tissue perfusion in cell survival and engraftment. Generation of safe and integration free myogenic progenitors from ES and iPS cells would be other goal of his lab.

His lab is currently funded by a Muscular Dystrophy Association (MDA) research grant award over a period of three years to develop methods using stem cells to regenerate skeletal muscle tissue in a mouse model of Duchenne Muscular Dystrophy (DMD).

Ongoing Research Projects

    • Role of local tissue perfusion on survival and engraftment of human ES/ iPS derived myogenic progenitors  in skeletal muscle
    • Generation of integration free and safe myogenic progenitors from human ES/ iPS cells
    • Systemic cell delivery approaches for cell therapy in muscular dystrophies
    • Using bio-scaffolds for cell delivery

 

Selected Publications

      1. Darabi R, Gehlbach K, Bachoo MR, Kamath S, Osawa M, Kam KE, Kyba M, Perlingeiro RCR. Functional skeletal muscle regeneration from differentiating embryonic stem cells. Nature Medicine, 2008; 14 (2): 134-143.
      2. Darabi R, Baik J, Clee M, Kyba M, Tupler R, Perlingeiro RC. Engraftment of embryonic stem cell- derived myogenic progenitors in a dominant model of muscular dystrophy. Experimental Neurology, 2009 Nov; 220(1):212-6.
      3. Ramos AL, Darabi R (equal contribution), Akbarloo N, Borges L, Catanese J, Dineen SP, Brekken RA, Perlingeiro RC. Clonal Analysis Reveals a Common Progenitor for Endothelial, Myeloid, and Lymphoid Precursors in Umbilical Cord Blood. Circulation Research, 2010 Dec 10; 107(12):1460-9.
      4. Darabi R, Santos FN, Filareto A, Pan W, Koene R, Rudnicki MA, Kyba M, Perlingeiro RC. Assessment of the myogenic stem cell compartment following transplantation of pax3/pax7-induced embryonic stem cell-derived progenitors. Stem Cells, 2011 May;29(5):777-90.
      5. Darabi R, Arpke RW, Irion S, Dimos JT, Grskovic M, Kyba M, Perlingeiro RC. Human ES- and iPS-Derived Myogenic Progenitors Restore Dystrophin and Improve Contractility upon Transplantation in Dystrophic Mice. Cell Stem Cell, 2012 May; 10 (5), 610-619.
      6. Filareto A, Parker S, Darabi R, Borges L, Iacovino M, Schaaf T, Mayerhofer T, Chamberlain J, Ervasti J, Scott McIvor R, Kyba M, Perlingeiro RCR. An ex vivo Gene Therapy Approach to Treat Muscular Dystrophy Using iPS cells. (Nature Communications, 2013;4:1549).
      7. Arpke RW, Darabi R, Mader TL, Zhang Y, Toyama A, Lontree CL, Nash N, Lowe DA, Perlingeiro RC, Kyba M. A New Immuno- Dystrophin- Deficient Model, The NSG-mdx4cv Mouse, Provides Evidence for Functional Improvement Following Allogenic Satellite Cell Transplantation. Stem Cells, 2013 Apr 19. doi: 10.1002/stem.1402.

Darabi Research Images