The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases

 Philip P. Foster, M.D., Ph.D.,

Philip P. Foster, M.D., Ph.D.,

Assistant Professor, Center for Proteomics and Systems Biology

Philip.P.Foster@uth.tmc.edu

(713) 486-5423

Philip P. Foster, M.D., Ph.D., is a physician and research scientist who has achieved international acclaim for his exceptional and original research contributions that span a broad spectrum of biology of oxygen to applied operational or basic research for the National Aeronautics and Space Administration. Philip obtained his MD degree (Thesis, Summa Cum Laude), from the University of Grenoble, France, where he also did his residency and clinical fellowship in Pulmonary Function Testing. Philip did another clinical fellowship in diving/hyperbaric medicine at the University of Nice, France. He obtained his PhD (Summa Cum Laude) in the Physiology and Biology of Extreme Environments at the University of Lyon, France. His Habilitation was obtained at the University of Saint Etienne, France. The Habilitation is the highest academic qualification a scholar can achieve by his or her own pursuit in several European and some Asian countries. Earned after obtaining a research doctorate, such as a PhD, habilitation requires the candidate to write a professorial thesis (See Wikipedia). Philip joined the University of Texas Health Science Center at Houston with affiliations at the Brown Foundation, Institute of Molecular Medicine (IMM), Department of NanoMedicine & Bioengineering, and Division of Pulmonary, Sleep Medicine, & Critical Care, Department of Internal Medicine in February 2013.

His research work has encompassed medicine, physiology, biology, biochemistry, mathematical/stochastic modeling & programming. Philip recently contributed to an extraordinary scientific achievement from basic research to innovative Human application: the success in hand-made assembly of the International Space Station in the most hostile environment that man ever had to face (spatial void, absence of gravity, extreme temperatures). Products and procedures were delivered to NASA. Dr. Foster received several international awards (competition across scientific fields) from NASA (Houston) (two awards), the Wellcome Trust (London), the European Space Agency (ESA) and Rouquayrol and Denayrouze Prize (Paris). Dr. Foster has over 410 citations for his journal articles, including Nature and Lancet. Philip has three textbooks and booklet. One of his scientific books became a success in store with several re-editions and has sold more than 15,000 copies worldwide. One article scored about 8,000 total views in less than one year after publication, making it among the highest-performing articles of the journal, 3,000 article downloads and 2,603 author’s profile views. Further, he is also making scientific contributions to the field of neuroscience (cognitive impairment and Alzheimer’s disease). Dr. Foster’s new challenge will be to develop biomarkers (X-aptamers) or protein discovery to elucidate exercise-induced and O2-induced neurogenesis and their implications for cognitive plasticity. Characterize the molecular mechanisms that regulate O2-induced neurogenesis, neural differentiation in human neural stem cells & proliferation of cancer stem cells.

Dr. Foster’s (nonprofit) Foundation is at www.BFOR-Foundation.org

ARTICLES IN PEER-REVIEWED JOURNALS

  • Foster PP. “How does dancing promote brain reconditioning in the elderly? Front. Ag. Neurosci., doi: 10.3389/fnagi.2013.00004. Epub 2013 Feb 26. 
  • Foster PP. The "brain-skin connection" in protein misfolding and amyloid deposits: embryological, pathophysiological, and therapeutic common grounds? Front Neurol 3: 56, 2012. 
  • Foster PP, Pollock NW, Conkin J, Dervay JP, Caillot N, Chhikara RJ, Vann RD, Butler BD, and Gernhardt ML. Protective Mechanisms in Hypobaric Decompression. Aviat. Space Environ. Med. 84:3, 212-25, 2013. 
  • Jørgensen A, Foster PP, Wisløff U, Paulsen G, Havnes MB, Eftedal I, and Brubakk AO. Eccentric exercise-induced myofibrillar disruption with sarcolemmal integrity prior to delayed diving has no effect on vascular bubble formation in rats, Eur. J. Appl. Physiol. 2012. 
  • Foster PP, Rosenblatt KP, Kuljiš RO. Exercise-induced cognitive plasticity, implications for mild cognitive impairment and Alzheimer's disease. Front Neurol 2: 28, 2011. 
  • Foster PP, Butler BD: Decompression to altitude: assumptions, experimental evidence, and future directions. Highlighted Topic-Invited Review. J Appl Physiol 106: 678-690, 2009. 
  • Cantais E, Louge P, Suppini A, Foster PP, Palmier B. Right-to-left shunt and risk of decompression illness with cochleo-vestibular and cerebral symptoms in divers: case control study in 101 consecutive dive accidents. Crit. Care Med. 31(1):84-8, 2003. 
  • Foster PP, Boriek AM, Butler BD, Gernhardt ML, Bové AA: Patent foramen ovale and paradoxical systemic embolism: a bibliographic review. Aviat. Space Environ. Med. 74(6, Suppl.):B1-B64, 2003. 
  • Woodruff KK, Johnson AN, Lee SMC, Gernhardt ML, Schneider SM, Foster PP: A pilot study for applying an extravehicular activity exercise prebreathe Protocol to the International Space Station. NASA Technical Memo 2000-210132, 2000. 
  • Foster PP, Feiveson AH, Glowinski R, Izygon M, Boriek AM: A model for influence of exercise on formation and growth of tissue bubbles during altitude decompression. Am. J. Physiol.: Regulatory Integrative and Comparative Physiology 279:R2304-R2316, 2000. This paper about mathematical modeling the physiology of O2 and N2 transport in tissues links us to the influential mathematician Paul Erdos. We are therefore assigned a finite Erdos number of 4 since Pr. Roland Glowinski has and Erdos number of 3. (http://en.wikipedia.org/wiki/erdos_number) 
  • Foster PP, Feiveson AH, Boriek AM: Predicting time to decompression illness during exercise at altitude, based on formation and growth of bubbles. Am. J. Physiol.: Regulatory Integrative and Comparative Physiology 279:R2317-R2328, 2000. 
  • Lee MCS, Moore AD, Fritsch-Yelle JM, Greenisen M, Schneider SM, Foster PP. Effect of in-flight exercise and extravehicular activity on postflight stand tests. NASA Technical Memo 2000-210185, 2000. 
  • Foster PP, Conkin J, Waligora JM, Powell MR, Chhikara RS: Role of metabolic gases in bubble formation during hypobaric exposures. J. Appl. Physiol., 84(3):1088-1095, 1998. 
  • Conkin J, Foster PP, Powell MR: Evolved gas, pain, the power law, and probability of hypobaric decompression sickness. Aviat. Space Environ. Med., 69:352-359, 1998. 
  • Conkin J, Powell MR, Foster PP, Waligora JM: Information about circulating microbubbles improves prediction of hypobaric decompression sickness. Aviat. Space Environ. Med., 69:8-16, 1998. 
  • Conkin J, Foster PP, Powell MR, Waligora JM: Relationship of the time course of venous gas bubbles to altitude decompression sickness. Undersea Hyperbaric Med., 23:141-49, 1996. 
  • Conkin J, Kumar KV, Powell MR, Foster PP, Waligora JM: A probability model of hypobaric decompression sickness based on 66 chamber tests. Aviat. Space Environ. Med., 67:176-83, 1996. 

 BOOKS

  • Foster PP: SCUBA Diving. Physiological Adaptations of the Body and Ensuing Limits. ("La plongee sous-marine a l'air. L'adaptation de l'organismDr. Philip P. Foster Published Bookse et ses limites.") PUG (Presses Universitaires de Grenoble) in 1993, EDP (Edition Diffusion Presse Science, Paris).[Textbook published in Belgium, Canada, France, and Switzerland. Approved by the “Commission Nationale Française de Médecine de la Plongée” (1994). Official textbook of “Fédération Française de Sports et d’Etudes Sous-Marins” (1997). Support from “Société Savante de Médecine de la Plongée” (1997). Rouquayrol et Denayrouze Award (1998).]. Sales success in bookstores & Amazon. 
  • Foster PP, Boriek AM, Butler BD, Gernhardt ML, Bové AA:Patent Foramen Ovale and Paradoxical Systemic Embolism: a Bibliographic Review. Aviat. Space Environ. Med. 74(6, Suppl.):B1-B64, 2003.[Supplement. Exhaustive work on Paradoxical Embolism of Gas and Thrombi, 64 pages.]

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