The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases

 Manuel Gonzalez-Garay, Ph.D.

Manuel Gonzalez-Garay, Ph.D.

Assistant Professor, Center for Molecular Imaging

Manuel.L.GonzalezGaray@uth.tmc.edu

713-500-3032

Dr. Gonzalez-Garay obtained his B.S. from the University of Nuevo Leon, Mexico in 1988. He wrote a bachelor's research dissertation “Papillomavirus and cervical cancer in Mexican population” under the supervision of Dr. Barrera-Saldana and Dr. Gariglio. After a pre-doctoral fellowship at University of Texas, he joined the doctoral program in 1990. In 1996, Dr. Gonzalez-Garay completed his Ph.D. at the University of Texas, writing a dissertation about the regulation of the stoichiometry of tubulin.  After a two-year Post-Doctoral Fellowship in the lab of Dr. Fernando Cabral, he joined Lexicon Genetics as a Bioinformatician. He was subsequently promoted to manager of Bioinformatics Group. During his stay at Lexicon Genetics, Dr. Gonzalez-Garay developed a large number of proprietary software and databases to support the gene knockout and drug  discovery pipelines.

During 2002, Dr. Gonzalez-Garay moved to Baylor College of Medicine, Human Genome Sequencing Center (HGSC) where he working as a Senior Scientific Programmer and team leader. During his stay at the HGSC he developed “Genboree discovery system” and participated as a bioinformatician in a large number of sequencing projects including the sequencing of the Human chromosome 3 and 12, the complete genomes of Rat and Sea Urchin. Dr. Gonzalez-Garay was instrumental in the development of pipelines for the re-sequencing of candidate genes at HGSC. From 2007 to 2009 he actively participated in the Tumor Sequencing Project (TSP) and the cancer genome atlas (TCGA) project.

In January, 2010, The IMM recruited Dr. Gonzalez-Garay as Research Assistant Professor for The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases. Dr. Gonzalez-Garay is currently developing the pipelines to analyze whole genome and exome sequences and he is currently participating in three main projects: The identification of the causal mutations for tuberous sclerosis, cardiomyopathy and schizophrenia.

Selected peer-reviewed publications (in chronological order).

  1. Gonzalez-Garay, M. L., and F. Cabral.  1995.  Overexpression of an epitope-tagged beta-tubulin in Chinese hamster ovary cells causes an increase in endogenous alpha-tubulin synthesis.  Cell Motil Cytoskeleton 31:259-272. PMID: 7553913
  2. Gonzalez-Garay, M. L., and F. Cabral. 1996. Alpha-Tubulin Limits Its Own Synthesis: Evidence for a Mechanism Involving Translational Repression. J Cell Biol. 135:1525-34. PMID: 8978820
  3. Gonzalez-Garay, M. L., Chang, L., Blade, K., Menick, D. R., and Cabral, F. (1999). A beta-tubulin leucine cluster involved in microtubule assembly and paclitaxel resistance. J Biol Chem 274: 23875-82. PMID: 10446152
  4. Barlow SB, Gonzalez-Garay M.L, Cabral F. 2002. Paclitaxel-dependent mutants have severely reduced microtubule assembly and reduced tubulin synthesis. J Cell Sci. 115:3469-3478. PMID: 12154077
  5. The Rat Genome Sequencing Project Consortium.  2004. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature 428:493-521. PMID: 15057822
  6. The Human Chromosome 12 Group.  2006. The finished DNA sequence of human chromosome 12. Nature 440:346-51. PMID: 16541075
  7. The Human Chromosome 3 Group.  2006. The DNA sequence, annotation and analysis of human chromosome 3. Nature 440:1194-8. PMID: 16641997
  8. Sea Urchin Genome Sequencing Consortium.  2006. The genome of the sea urchin Strongylocentrotus purpuratus. Science 314:941-52. PMID: 17095691
  9. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. 2008. Nature 455:1061-1068. PMID: 18772890
  10. Somatic mutations affect key pathways in lung adenocarcinoma.  2008. Nature 455:1069-1075. PMID:18948947