Dachun Wang, M.D.
Assistant Professor, Center for Immunology and Autoimmune DiseaseDachun.Wang@uth.tmc.edu
Dachun Wang received his M.D. degree from Fujian University of Medical Sciences and graduate training at Sun Yat-Sen University of Medical Sciences and Institute of Forensic Sciences of Justice Department in China, where he focused on the study of wound-healing responses to tissue injury.
Dachun Wang pursued his postdoctoral training in the Laboratories of Dr. Maximilian L. Buja and Dr. Steven J. Norris in the Department of Pathology, UT Medical School at Houston and then obtained further postdoctoral training on genetic manipulation of ES cells in Dr. Rick A. Wetsel’s Laboratory in the Research Center for Immunology and Autoimmune Diseases from 2003, where he was subsequently promoted to Research Scientist in 2005 and then to Instructor in 2008.
Dachun Wang’s research projects are focusing on 1) to direct human embryonic stem (hES) cell differentiation into pure populations of lung resident stem cells/progenitors, such as alveolar type II (ATII) epithelial cells and lower airway Clara cells, by genetic selection, and 2) to generate a universal donor human embryonic stem cell line to provide a transplantable cell source for cell based therapy or tissue regeneration without causing draft rejection by recipient immune system. A pure population of AT II cells derived from human embryonic stem cell has been successfully generated. These cells possess the potential to proliferate, give rise to colonies and differentiate into alveolar type I (AT I) epithelial cells in vitro and hold promise to be a practical transplantable source to replace defective or damaged alveolar epithelium in future, such as therapeutic treatment of surfactant protein deficiencies and idiopathic pulmonary fibrosis. Bleomycin induced mouse model of pulmonary fibrosis is being utilized to investigate the therapeutic potential of the hES cell derived AT II cells.