The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases

 David Gorenstein, Ph.D.

David Gorenstein, Ph.D.

Associate Dean for Research, School of Medicine
Chair, Department of NanoMedicine and Biomedical Engineering
Deputy Director and James T. Willerson Distinguished Chair
Director, IMM Center for Proteomics and Systems Biology

David.G.Gorenstein@uth.tmc.edu

713-500-2233

David Gorenstein, Ph.D., joined UTHealth January 1, 2009 as Professor and Deputy Director of the IMM. Dr. Gorenstein. He was most recently the Associate Dean for Research, School of Medicine, the University of Texas Medical Branch at Galveston (UTMB) and the Charles Marc Pomerat Distinguished Professor in the Departments of Biochemistry & Molecular Biology and Neurosciences & Cell Biology. He also served as the founding Director of the UTMB Sealy Center for Structural Biology and Director of the Gulf Coast Consortium in Magnetic Resonance, a shared facility that includes UTMB, Rice University, Baylor College of Medicine, the University of Houston, UTHealth and UT M.D. Anderson Cancer Center. He has nearly 40 years experience in structural biology, drug design, nucleic acid and protein chemistry with over 240 publications.  He currently has major translational research programs in proteomics and nanomedicine for both diagnostics and therapeutics, particularly in cancer. He also has major programs in next-generation aptamer technologies and NMR structural biology, drug design, nucleic acid and protein chemistry.

Dr. Gorenstein received a bachelors degree in chemistry from the Massachusetts Institute of Technology and a masters degree and doctorate in chemistry from Harvard University. Before moving to the Houston/Galveston area, he held faculty positions in the Departments of Chemistry at the University of Illinois at Chicago and Purdue University. He has received a number of awards, including Guggenheim (to the University of California San Francisco) and senior Fulbright (to Oxford University, England) fellowships and election as Fellow to the American Association for the Advancement of Science. Dr. Gorenstein holds over three dozen patents on novel aptamer technology (awarded and pending), many of which have been licensed to AptaMed and AM Biotechnologies, Galveston and Houston companies he founded.

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Publications (1998 - Present)
Thioaptamers targeting Dengue virus type-2 envelope protein domain III
S H A Gandham, D E Volk, L G L Rao, N. Neerathilingam and D G Gorenstein
Biochem Biophys Res Commun. 2014 (in press)
Bone marrow endothelium-targeted therapeutics for metastatic breast cancer
J Mai, Y Huang, C Mu, G Zhang, R Xu, X Guo, X Xia, D E Volk, G L Lokesh, V Thiviyanathan, D G Gorenstein, X Liu, M Ferrari, H Shen
J. Control Release 187, 22-29, 2014.
Aptamers and the next generation of diagnostic reagents.
Varatharasa Thiviyanathan and David G. Gorenstein,
Proteomics Clin. Appl.
, 2012 6(11-12): 563-73. DOI:10.1002/prca.201200042
X-Aptamers: A bead-based selection method for random incorporation of drug-like moieties onto next-generation aptamers for enhanced binding
Weiguo He, Miguel-Angel Elizondo-Riojas, Xin Li, Ganesh Lakshmana Rao Lokesh, Anoma Somasunderam, Varatharasa Thiviyanathan, David E. Volk, Ross H. Durland, Johnnie Englehardt, Claudio N. Cavasotto, David G. Gorenstein,
Biochemistry
, 2012, 51(42):8321-8323. - Click here for PMC Free PDF
Aggregation Behavior of Ibuprofen, cholic acid and dodecylphosphocholine
P Prakash, A. Sayyed-Ahmad, Y. Zhou, D E Volk, D G Gorenstein, E. Dial, L M Lichtenberger, A A Gorfe, BBA- Membranes 1818(12), 3040-3047, 2012.
Insight into NSAID-induced membrane alterations, pathogenesis and therapeutics: characterization of interaction of NSAIDs with phosphatidylcholine
L M Lichtenberger, V Jayaraman, J R Doyen, R G O’Neil, E J Dial, Y Yong Zhou, D E Volk, D G Gorenstein, U Marathi, M B Boggara, R Krishnamoorti, Biochim. et Biophys. Acta (BBA) - Molecular and Cell Biology of Lipids, 2012, 1821: 7. 994-1002.
NMR Structural studies of thymosin alpha-1 and b-thymosins
Volk, D. E., Tuthill, C.W., Elizondo-Riojas, M.-A. and Gorenstein, D.G., Ann. N.Y. Acad. Sci. 2012 1270:73-78.
NMR Structure of Human Thymosin Alpha-1
Elizondo-Riojas, M.-A., Chamow, S.M., Tuthill, C.W., Gorenstein, D.G., Volk, D.E., Biochem. & Biophys. Res. Commun., 2011, 416:356-361. PMC3419375
Thioaptamer Conjugated Liposomes for Tumor Vasculature Targeting.
A.P. Mann, R.C. Bhavane, A. Somasunderam, B.L. Montalvo-Ortiz, K.B. Ghaghada, D. Volk, R. Nieves-Alicea, K.S. Suh, M. Ferrari, A. Annapragada, D.G. Gorenstein, T. Tanaka, Oncotarget 2(4), 298-304, 2011.

E-selectin-Targeted Porous Silicon Particle for Nanoparticle Delivery to the Bone Marrow.
Mann AP, Somasunderam A, Liu, X., Gorenstein DG, Ferrari, M.
Adv. Mater. 23(36):H278-H282, 2011.

Identification of thioaptamer ligand against E-selectin: potential application for inflammed vasculature imaging.
Mann AP, Somasunderam A, Nieves-Alicea R, Li X, Hu A, Sood AK, Ferrari M, Gorenstein DG, Tanaka T.
PLoS One 2010 Sep 30;5(9). pii: e13050.

Combinatorial selection of DNA thioaptamers targeted to the HA binding domain of CD44.
Somasunderam A, Thiviyanathan V, Tanaka T, Li X, Neerathilingam M, Lokesh GL, Mann A, Peng Y, Ferrari M, Klostergaard J, Gorenstein DG.
Biochemistry 49:9106-9112, 2010.

Proteomic Analysis of Pichinde virus Infection Identifies Differential Expression of Prothymosin-α
G. C. Bowick, K. V. Soman, H. Wang, J. F. Aronson, B. A. Luxon, L. O. Lomas,D. G. Gorenstein, and N. K. Herzog 
J. Biomed. & Biotech.Epub ahead of press.
Role of BC loop residues in structure, function and antigenicity of the West Nile virus envelope protein receptor binding domain III. 
Shuliu Zhang, Evgeniy I. Bovshik, Rodrigo Maillard, Gregory D. Gromowski, David E. Volk, Catherine H. Schein, Claire Y.-H. Huang, David G. Gorenstein, James C. Lee, Alan D. T. Barrett and David W.C. Beasley 
Virology403(1):85-91, 2010.
Structure of Yellow Fever Virus Envelope Protein Domain III
D. E. Volk, F. J. May, S. H. Gandham, A. Anderson, J. von Lindern, 
D. Beasley, A. D.T. Barrett and D. G. Gorenstein. 
Virology394(1), 12-18, 2009.
Structural and Functional Elements of the Promoter Encoded by 5'UTR of Venezuelan Equine Encephalitis Virus Genome
R. Kulasegaran-Shylini, S. Atasheva, D. G. Gorenstein and I. Frolov 
J. Virology 83(17):8327-39, 2009.
The 5'UTR-specific mutation in VEEV TC-83 genome has a strong effect on RNA replication and subgenomic RNA synthesis, but not on translation of the endoced proteins. 
R. Kulasegaran-Shylini, V. Thiviyanathan, D. G. Gorenstein and I. Frolov 
Virology 387:211-221, 2009.
Analysis of the Differential Host Cell Nuclear Proteome Induced by Attenuated and Virulent Homorrhagic Arenavirus Infection. 
G.C. Bowick, H.M. Spratt, A.E. Hogg, J.J. Endsley, J.E. Wiktorowicz, A. Kuroshy, B.A. Luxon, D.G. Gorenstein and N.K Herzog 
J. Virol. 83:687-700, 2009.
NMR Assignments of the Sylvatic Dengue 1 Virus Envelope Protein Domain III. 
D. E. Volk, K. M. Anderson, S. H. A. Gandham, F. J. May, L. Li, David W. C. Beasley, A. D. T. Barrett and D. G. Gorenstein 
Biomol. NMR Assigments 2:155-157, 2008.
Base-pairing Properties of the Oxidized Cytosine Derivative, 5-Hydroxy Uracil.
V. Thiviyanathan, A. Somasunderam, D. E. Volk, T.K. Hazra, S. Mitra and D. G. Gorenstein 
Biochem. Biophys. Res. Commun. 366:752-757, 2008.
Combinatorial selection of a single stranded DNA thioaptamer targeting TGF-beta-1 protein. 
J. Kang, M. S. Lee, J. A. Copland, B. A. Luxon and D. G. Gorenstein 
Bioorg. Med. Chem. Lett. 18(6):1835-1839, 2008. 
Bead-based Approaches to Develop Thioaptamers for Diagnostics and Therapeutics. 
X. Yang, D. Beasley, J. Engelhardt, M. Shumbera, B. A. Luxon and D. G. Gorenstein 
Phosphorus, Sulfur, and Silicon and the Related Elements 183(2):469-472, 2008. 
Ab initio base-pairing energies of an oxidized thymine product, 5-formyluracil, 
with standard DNA bases at the BSSE-free DFT and MP2 theory levels.
 
D. E. Volk, V. Thiviyanathan, A. Somasunderam and D. G. Gorenstein, 
Org. Biomol. Chem. 2007, 5(10), 1554-1558.
NMR Assignments of the Yellow Fever Virus Envelope Protein Domain III 
D. E. Volk, S. A. Gandham, F. J. May, A. Anderson, A. D. T. Barrett and D. G. Gorenstein. 
Biomolecular NMR Assignments 2007, 1(1):49-50, 2007.
Solution Structure of the Envelope Protein Domain III of Dengue-4 Virus 
D. E. Volk, Y.-C. Lee, X. Li, V. Thiviyanathan, G. D. Gromowski, L. Li, A. Lamb, D. W. Beasley, A. D. T. Barrett and D. G. Gorenstein, 
Virology 2007, 364(1), 147-154. (PMCID: PMC1950219)
Magnesium ion is an effective inhibitor of Escherichia coli to heparin. 
J. Kang, M. S. Lee & D. G. Gorenstein, 
J. Microbiol. Methods 71(3):340-342, 2007. 
Combinatorial Selection of a RNA Thioaptamer that binds to Venezuelan Equine Encephalitis Virus Capsid Protein. 
J. Kang, M. S. Lee, S. J. Watowich and D. G. Gorenstein 
FEBS Lett. 581(13):2497-2502, 2007. 
Application of RNase in the purification of RNA-binding proteins. 
J. Kang, M. S. Lee and D. G. Gorenstein, 
Anal. Biochem. 365(1):147-148, 2007.
Thioaptamer Decoy Targeting AP-1 Proteins Influences Cytokine Expression and the Outcome of Arenavirus Infections. 
S. M. Fennewald, E. P. Scott, L. H. Zhang, J. F. Aronson, D. G. Gorenstein, 
B. A. Luxon, R. E. Shope, D. W. C. Beasley and N. K. Herzog. 
J. Gen. Virol. 2007, 88:981-990. 
Combinatorial selection and delivery of thioaptamers. 
V. Thiviyanathan, A. D. Somasunderam and D. G. Gorenstein 
Biochem. Soc. Trans. 2007, 35:50-52. 
Characterization of heparin-living bacteria interactions by chemiluminescence electrophoretic mobility shift assay. 
J. Kang, M. S. Lee and D. G. Gorenstein 
Anal. Biochem. 2007, 363(2):312-314. (PMCID:PMC1987369)
Identification of Differentially Activated Cell-Signaling Networks Associated with Pichinde Virus Pathogenesis Using Systems Kinomics. 
G. C. Bowick, S. M. Fennewald, E. P. Scott, L. H. Zhang, B. L. Elsom, 
J. F. Aronson, H. M. Spratt, B. A. Luxon, D. G. Gorenstein and N. K. Herzog. 
Journal of Virology 2007, 81(4):1923-1933. (PMCID:PMC1797588)
Differential Signaling Networks Induced by Mild and Lethal Hemorrhagic Fever Virus Infections. 
G. C. Bowick, S. M. Fennewald, E. P. Scott, L. H. Zhang, B. L. Elsom, 
J. F. Aronson, H. M. Spratt, B. A. Luxon, D. G. Gorenstein and N. K. Herzog. 
Journal of Virology 2006, 80(20):10248-10252. (PMCID: PMC1617297)
NMR Assignment of the Dengue 4 Virus Envelope Protein Domain III 
D. E. Volk, Y.-C. Lee, X. Li, A. D. T. Barrett and D. G. Gorenstein, 
Journal of Biomolecular NMR 2006, 36(suppl. 5):62.
Delivery of double-stranded DNA thioaptamers into HIV-1 infected cells for antiviral activity 
M. R. Ferguson, D. R. Rojo, A. Somasunderam, V. Thiviyanathan, B. Ridley, X. Yang and D.G. Gorenstein 
Biochem. Biophys. Res. Commun. 2006, 344(3), 792-797.
Ab Initio Base-pairing Energies of Uracil and 5-Hydroxy-Uracil with Standard DNA Bases at the BSSE-free DFT and MP2 Theory Levels 
D. E. Volk, V. Thiviyanathan, A. Somasunderam and D. G. Gorenstein 
Organic and Biomolecular Chemistry 2006, 4(9), 1741-1745.
Identification of proteins bound to a thioaptamer probe on a proteomics array. 
H. Wang, X. Yang, G. C. Bowick, N. K. Herzog, L. O. Lomas, B. A. Luxon and D. G. Gorenstein 
Biochem. Biophys. Res. Commun. 2006 , 347(3), 586-593.
Structure of the Envelope Protein Domain III of Omsk Hemorrhagic Fever Virus. 
D. E. Volk, L. Chavez, D. W. C. Beasley, A. D. T. Barrett, M. R. Holbrook and D. G. Gorenstein 
Virology 2006, 351(1), 188-195.
Chemiluminescence-based electrophoretic mobility shift assay of heparin-protein interactions. 
J. Kang, M. S. Lee and D.G. Gorenstein 
Analytical Biochemistry 2006 , 349(1), 156-158.
Selection of Thioaptamers for Diagnostics and Therapeutics 
X. Yang, H. Wang, D.W.C. Beasley, D. E. Volk, X. Zhao, B. A. Luxon, 
L. O. Lomas, N. Herzog, J. F. Aronson, A.D.T. Barrett, J. F. Leary and D. G. Gorenstein 
Annal. N. Y. Acad. Sci. 2006, 1082:116-119.
Chemiluminescence-based electrophoretic mobility shift assay of RNA-protein interactions: Application to binding of viral capsid proteins to RNA. 
J. Kang, M. S. Lee, S. J. Watowich and D.G. Gorenstein 
Journal of Virological Methods 2006, 131(2), 155-159.
5-Hydroxy Uracil Can Form Stable Base Pairs With all Four Bases in a DNA Duplex. 
V. Thiviyanathan, A. Somasunderam, D.E. Volk, and D.G. Gorenstein 
Chemical Communications. 2005(3) 400-402.
Quantitative analysis of chemiluminescence signals using a cooled charge-coupled device camera. 
J. Kang, M. S. Lee and D.G. Gorenstein 
Analytical Biochemistry 2005, 345(1), 66-71. 
The enhancement of PCR amplification of a random sequence DNA library by DMSO and betaine: application to in vitro combinatorial selection of aptamers. 
J. Kang, M. S. Lee and D.G. Gorenstein 
Journal of Biochemical and Biophysical Methods 2005, 64(2), 147-151.
The effects of thiophosphate substitutions on native siRNA gene silencing. 
Xheng-Yin Li, Haibo Mao, Deborah A. Kallick and David G. Gorenstein 
Biochem. Biophys. Res. Commun. 2005 , 329(3), 1026-1030.
Combinatorial Selection, Inhibition and Antiviral Activity of DNA Thioaptamers Targeting the RNase H Domain of HIV-1 Reverse Transcriptase. 
A. Somasunderam, M. R. Ferguson, D. R. Rojo, V. Thiviyanathan, X. Li, W. A. O'Brien and D.G. Gorenstein 
Biochemistry 2005 , 44(30), 10388-10395.
Progress in Thioaptamer Development 
Xianbin Yang and David G. Gorenstein 
Current Drug Targets 2004, 5, 705-715.
TATA-Box Binding Protein Induces Structure in the Recombinant Glucocorticoid Receptor AF1 Domain. 
R. Kumar, D.E. Volk, J. Li, J.C. Lee, D.G. Gorenstein and E.B. Thompson 
Proc. Nat. Acad. Sci. U.S.A. 2004, 101, 16425-16430. (PMCID: PMC534534)
High-resolution structure of a picornaviral internal cis-acting RNA replication element (cre). 
V. Thiviyanathan, Y. Yang, K. Kaluarachchi, R. Rijnbrand, D.G. Gorenstein and S. M. Lemon 
Proc. Nat. Acad. Sci. U.S.A. 2004, 101, 12688-12693. (PMCID: PMC515117)
Mutational and Structural Analysis of Stem-Loop IIIc of the Hepatitis C Virus and GB Virus B Internal Ribosome Entry Sites. 
R. Rijnbrand, V. Thiviyanathan, K. Kaluarachchi, S. M. Lemon and D.G. Gorenstein 
J. Mol. Biol. 2004, 343, 805-817.
Combinatorial Selection and Edited Combinatorial Selection of Phosphorothioate Aptamers Targeting Human Nuclear Factor-kappaB RelA/p50 and RelA/RelA. 
S.E. Bassett, S. M. Fennewald, D. J. King, X. Li, N. K. Herzog, R. Shope, J. F. Aronson, B. A. Luxon and D.G. Gorenstein 
Biochemistry 2004, 43(28), 9105-9115.
Solution structure and antibody binding studies of the envelope protein domain III from the New York strain of West Nile virus. 
D.E. Volk, D. W. C. Beasley, D. A. Kallick, M.R. Holbrook, A.D.T. Barrett and D. G. Gorenstein 
J. Biolog. Chem. 2004, 279,38755-38761.
1H, 13C, and 15N resonance assignments for domain III of the West Nile Virus envelope protein.
D.E. Volk, D. A. Kallick, M.R. Holbrook, D.W.C. Beasley, A.D.T. Barrett and D.G. Gorenstein 
J. Biomol. NMR 2004, 29, 445-446.
NMR Structure of the Apo-S100P protein. 
Y.-C. Lee, D.E. Volk, V. Thiviyanathan, Q. Kleerekoper, A.X. Gribenko, S. Zhang D.G. Gorenstein, G. I. Makhatadze and B. A. Luxon. 
J. Biomol. NMR 2004, 29, 399-402.
Solution Structure of a Cis-Opened (10R)-N6- Deoxyadenosine Adduct of
(9S,10R)-9,10-Epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in a DNA Duplex 

D.E. Volk, V. Thiviyanathan, J.S. Rice, B.A. Luxon, J.H. Shah, H. Yagi, J.M. Sayer, D.M. Jerina, and D.G. Gorenstein 
Biochemistry 2003, 42, 1410-1420.
Initiation of Repair of A:G Mismatches is Modulated by Sequence Context 
A.M. Sanchez, D.E. Volk, D.G. Gorenstein, and R.S. Lloyd 
DNA Repair 2003, 2(8), 863-878.
Solution Structure, Dynamics and Thermodynamics of the Native 
State Ensemble of the Sem-5 C-terminal SH3 Domain
 
J.C. Ferreon, D.E. Volk, B.A. Luxon, D.G. Gorenstein and V.J. Hilser, 
Biochemistry 2003, 42, 5582-5591.
Discrimination of components in atherosclerotic plaques from human carotid 
endarterectomy specimens by magnetic resonance imaging ex vivo
 
J. Morrisett, W. Vick, R. Sharma, G. Lawrie, M. Reardon, E. Ezell, 
J. Schwartz, G. Hunter, and D. Gorenstein 
Magnetic Resonance Imaging 2003, 21, 465-474.
Immunofluorescence assay and flow-cytometry selection of bead-bound aptamers 
X. Yang, X. Li, T.W. Prow, L.M. Reece, S.E. Bassett, B.A. Luxon, N.K. Herzog, 
J. Aronson, R.E. Shope, J.F. Leary and D.G. Gorenstein, 
Nucleic Acids Research 2003 31, e54. (PMCID: PMC156057)
Solution Structure of a DNA Duplex Containing 8-Hydroxy- 2'-Deoxyguanosine Opposite Deoxyguanosine 
V. Thiviyanathan, A. Somasunderam, T.K. Hazra, S. Mitra and D.G. Gorenstein 
Journal of Molecular Biology 2003, 325, 433-442.
Design of Bloch-Siegert phase-shift self-compensated pulses for HCN triple-resonance experiments 
S. Zhang and D.G. Gorenstein, 
Chemical Physics Letters 2002 362, 278-284.
Coherence Excitation with Phase-Incremented Pulses in Nuclear Magnetic Resonance 
S. Zhang and D.G. Gorenstein, 
Journal of Magnetic Resonance 2002 154, 73-79.
Combinatorial Selection and Binding of Phosphorothioate Aptamers Targeting Human NF-kB RelA(p65) and p50 
D.J. King S.E. Bassett, X. Li, S.A. Fennewald, N.K. Herzog, B.A. Luxon, R.E. Shope and D.G. Gorenstein, 
Biochemistry 2002 41, 9696-9706.
Solution structure and design of dithiophosphate backbone 
aptamers targeting transcription factor NF-kappa B 

D.E. Volk, X. Yang, S.M. Fennewald, D.J. King, S. Bassett, 
S. Venkitachalam, N. Herzog, B.A. Luxon, and D.G. Gorenstein, 
Bioorganic Chemistry 2002, 30, 396-419.
Construction and selection of bead-bound combinatorial oligonucleoside phosphorothioate 
and phosphorodithioate aptamer libraries designed for rapid PCR-based sequencing
 
X. Yang S.E. Bassett, X. Li, B.A. Luxon, N.K. Herzog, R.E. Shope, J. Aronson, T.W. Prow 
J.F. Leary, R. Kirby, A.D. Ellington and D.G. Gorenstein, 
Nucleic Acids Research 2002 30, e132. (PMCID: PMC137987)
Structure of Hybrid Backbone Methylphosphonate DNA Heteroduplexes: Effect of R and S Stereochemistry 
V. Thiviyanathan, K.V. Vyazovkina, E.K. Gozansky, E Bichenchova, T.V. Abramova, B.A. Luxon, A.V. Lebedev and D.G. Gorenstein 
Biochemistry 2002, 41, 827-838.
An ab initio study of phosphorothioate and phosphorodithioate interactions with sodium cation. 
D.E. Volk, T.D. Power, D.G. Gorenstein and B.A. Luxon, 
Tetrahedron Letters 2002, 43, 4443-4447.
Suppression of Linearly Responsive Residual Water, an invited review 
S. Zhang and D.G. Gorenstein, 
Concepts in Magnetic Resonance 2002 14, 102-111.
Separation of Synthetic Oligonucleotide Dithioates from Monothiophosphate Impurities by Anion-Exchange Chromatography on a Mono-Q Column 
X. Yang, R.P. Hodge, B.A. Luxon, R. Shope, and D.G. Gorenstein 
Analytical Biochemistry 2002 306, 92-99.
Potential Double-Flipping Mechanism by E. coli MutY. 
P.G. House, D.E. Volk, V. Thiviyanathan, R.C. Manual, B.A. Luxon, D.G. Gorenstein, and R.S. Lloyd, 
Progress in Nucleic Acid Research and Molecular Biology2001, 68, 349-364.
Cholera toxin-induced PGE2 activity is reduced by chemical reaction with L-histidine. 
J.W. Peterson, D. King, E.L. Ezell, M. Rogers, D. Gessell, J. Hoffpauer, L. Reuss, A.K. Chopra and D. Gorenstein, 
Biochimica et Biophysica Acta (BBA)- Molecular Basis of Disease 2001 1537, 27-41.
NMR Evidence for Syn-Anti Interconversion of a Trans Opened (10R)-dA Adduct of Benzo[a]pyrene (7S,8R)-Diol (9R,10S)-Epoxide in a DNA Duplex. 
D.E. Volk, J.S. Rice, B.A. Luxon, H.J.C. Yeh, C. Liang, G. Xie, J.M. Sayer, D.M. Jerina, and D.G. Gorenstein, 
Biochemistry 2000, 39, 14040-14053.
Solution Conformation of a Bulged Adenosine Base in an RNA Duplex by Relaxation Matrix Refinement 
V. Thiviyanathan, A.B. Guliaev, N.B. Leontis and D.G. Gorenstein 
Journal of Molecular Biology :2000, 300, 1143-1156.
Structural Similarities between MutT and the C-Terminal Domain of MutY. 
D.E. Volk, P.G. House,V. Thiviyanathan, B.A. Luxon, S. Zhang, R.S. Lloyd and D.G. Gorenstein, 
Biochemistry (Accelerated Publication) 2000, 39, 7331-7336.
Enhanced Suppression of Residual Water in a "270" WET Sequence 
S. Zhang, X. Yang and D.G. Gorenstein 
Journal of Magnetic Resonance 2000, 143, 382-386
Adiabatic Decoupling Sidebands 
S. Zhang and D.G. Gorenstein, 
Journal of Magnetic Resonance 2000, 144, 316-321.
Synchronized Adiabatic Decoupling 
S. Zhang and D.G. Gorenstein, 
Journal of Magnetic Resonance 2000, 147, 110-115.
Solution Structure and Local Conformational Dynamics of Lac Operators by 2D NMR 
K. Kaluarachchi, D.G. Gorenstein and B.A. Luxon 
Journal of Biomolecular Structure Dynamics 2000, 11, 123-134.
Absence of perilipin results in leanness and reverses obesity in Lepr^(db/db) mice. 
J. Martinez-Botas, J.B. Anderson, D. Tessier, A. Lapillonne, 
B. H-J. Change, M.J. Quast, D.G. Gorenstein, K-H. Chen and L. Chan, 
Nature Genetics 2000, 26, 474-479.
D.G. Gorenstein and B.A. Luxon, "31P NMR", in 
Encyclopedia of Spectroscopy and Spectrometry 
Eds., J. Lindon, G. Tanter and J. Holmes, pp 1735-1744, Acdemic Press (2000).
1H, 13C, and 15N resonance assignments of the C-terminal domain of MutY: An Adenine glycosylase active on G:A mismatches. 
D.E. Volk, V. Thiviyanathan, P.G. House, R.S. Lloyd and D.G. Gorenstein, 
J. Biomol. NMR1999, 14, 385-386.
E. Gozanski, V. Thiviyanathan, B.A. Luxon and D.G. Gorenstein, 
"Hybrid-Hybrid Matrix Method for 3D NOESY-NOESY Data Refinements", in 
Modern Techniques in Protein NMR 
N. Rama Krishna and L.J. Berliner, Eds., Plenum Press, Vol. 17, 163-199 (1999).
Multiple effective fields created by a periodic irradiation of radiofrequency field in NMR. 
S. Zhang and D.G. Gorenstein, 
Chemical Physics Letters 1999, 303, 587-592.
"Best" Homonuclear Adiabatic Decoupling for 13C and 15N Double-Labeled Proteins 
S. Zhang and D.G. Gorenstein, 
Journal of Magnetic Resonance 1999, 138, 281-287.
Automated 2D NOESY Assignment and Structure Calculation of Crambin(S22/I25) with the Self-Correcting Distance Geometry Based NOAH/DIAMOD Programs 
Y. Xu, J. Wu, D.G. Gorenstein and W. Braun, 
Journal of Magnetic Resonance 1999, 136, 76-85.
Aptamers containing thymidine 3'-O-phosphorodithioates: Synthesis and Binding to Nuclear Factor-kB 
X. Yang, S. Fennewald, B.A. Luxon, J. Aronson, N. Herzog and D.G. Gorenstein 
Bioorganic and Medicinal Chemistry Letters1999, 9, 3357-3362.
Measurement of 3JH3'-P with Watergate 
X. Yang, S. Zhang, B.A. Luxon, and D.G. Gorenstein 
NMR Newsletter1999, 495, 25-27.
Novel Combinatorial Selection of Phosphorothioate Oligonucleotide Aptamers 
D.J. King, D.A. Ventura, A.R. Brasier and D.G. Gorenstein, 
Biochemistry 1998, 37, 16489-16493.
Bloch-Siegert Shift Compensated and Cyclic Irradiation Sidebands Eliminated, Double-Adiabatic 
Homonuclear Decoupling for13C- and15N-Double-Labeled Proteins
 
S. Zhang and D.G. Gorenstein, 
Journal of Magnetic Resonance 1998, 132, 81-87.
V. Thiviyanathan, N. Illangasekara, E. Gozanski, F. Zhu, N.B. Leontis, B.A. Luxon and D.G. Gorenstein, 
"P-31 NOESY-NOESY Hybrid-Hybrid Matrix Refinement of a DNA Three-Way Junction", 
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