Dr. Roza Nurieva
The University of Texas MD Anderson Cancer Center
Department of Immunology
- Immune tolerance
- Developmental regulation of T helper subsets
- Tumor Immunology
Our research is to understand the molecular basis of T cell mediated immune responses, and how abnormal immune regulation leads to immunodeficiency, autoimmunity and cancer. These studies will help us to understand the function of the immune system, and will, therefore, help develop approaches to design drugs against cancer, as well as against autoimmune disorders.
A tutorial student would be involved in the research in the following projects: 1. The molecular mechanisms of T cell activation and tolerance; 2. The signaling and transcriptional mechanisms underlying T helper cell differentiation and function. This research direction will bridge the basic molecular biology and biochemistry to immune diseases and provide new ways of treating tumors.
A tutorial in this laboratory will provide training in molecular and cell biology techniques including molecular cloning, cell culture, mouse models, gene expression profiling, etc.
Nurieva RI, Zheng S, Jin W, Chung Y, Zhang Y, Martinez GJ, Reynolds JM, Wang SL, Lin X, Sun SC, Lozano G, Dong C. The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. 32(5):670-680, 2010.
Nurieva RI, Chung Y, Martinez GJ, Yang XO, Tanaka S, Matskevitch TD, Wang YH, Dong C. Bcl6 mediates the development of T follicular helper cells. Science 325(5943):1001-5, 2009.
Nurieva RI, Chung Y, Hwang D, Yang XO, Kang HS, Ma L, Wang YH, Watowich SS, Jetten AM, Tian Q, Dong C. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29(1):138-49, 2008.