Dr. Guang Peng
The University of Texas MD Anderson Cancer Center
Department of Clinical Cancer Prevention
- Cancer prevention
- Genomic instability
- DNA repair
- Replication stress
- Epigenetic regulation
The central focus of my research program is to apply the basic knowledge of genome maintenance mechanisms to early detection and cancer prevention. By using molecular, genetic and systems biology approaches, we aim to address two key questions: (1) Can we identify genetic and epigenetic alterations in the genome maintenance network at early stages of carcinogenesis, particularly during the transition from premalignant lesions to cancer? (2) Can we identify targeted prevention strategies for the premaliganant lesions with particular genetic alterations? The answers to these questions will lead to achieve the ultimate goal of personalized cancer prevention.
Projects/Techniques: A tutorial in my laboratory would provide students with an opportunity to gain experiences in molecular biology with a focus in the following areas:
1) The interplay between epigenetic regulation and genome maintenance
2) Cellular tolerance to replication stress
3) Dissecting dysfunctional DNA repair network with a systems biology approach
Peng G, Yim EK, Dai H, Jackson AP, Burgt I, Pan MR, Hu R, Li K, Lin SY. BRIT1/MCPH1 links chromatin remodeling to DNA damage response. Nat Cell Biol 11(7):865-72, 7/2009. e-Pub 6/2009. PMCID: PMC2714531.
Yim EK, Peng G, Dai H, Hu R, Li K, Lu Y, Mills GB, Meric-Bernstam F, Hennessy BT, Craven RJ, Lin SY. Rak functions as a tumor suppressor by regulating PTEN protein stability and function. Cancer Cell 15(4):304-14, 4/2009. PMCID: PMC2673492.
Yoon A, Peng G, Brandenburger Y, Brandenburg Y, Zollo O, Xu W, Rego E, Ruggero D. Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita. Science 312(5775):902-6, 5/2006.