Dr. Tomasz Zal
The University of Texas MD Anderson Cancer Center
Department of Immunology
- Immune surveillance
- Tumor immunology
- Tumor microenvironment
- Intravital cell motility and interactions
- Multiphoton microscopy
- Immunological synapse
- Gamma-delta T cells
My laboratory focuses on the understanding of the cellular and molecular mechanisms of immune tolerance and activation, including the immune response to tumors (or the lack thereof). We are particularly interested in visualizing the dynamics of T cell regulation in the microenvironment of the living tissue, such as inside tumors, lymphoid organs, and, for gamma-delta T cells, in various epithelia. At the molecular level, we are interested in the interactions and signal transduction by T cell receptor in the immunological synapse, especially in vivo.
Project 1: Using intravital multiphoton microscopy to visualize immune response and tolerance mechanisms during tumor progression.
Project 2: Investigating the role of T cell receptor and immunological synapse in the surveillance of bodily epithelia.
A tutorial in this laboratory would provide a hands-on experience with cutting edge intravital microscopy approaches to study immune regulation at a single cell level in vivo. It would also provide experience with DNA cloning, protein interactions and signal transduction analysis.
Intravital imaging of anti-tumor immune response and the tumor microenvironment. Zal T, Chodaczek G. Semin Immunopathol. 2010 Sep;32(3):305-17. Epub 2010 Jul 22. Review.
http://www.ncbi.nlm.nih.gov/pubmed/19065792. Zal T. Adv Exp Med Biol. 2008;640;183-97. Review.
Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse. Yachi PP, Ampudia J, Gascoigne NR, Zal T. Nat Immunol. 2005 Aug;6(8):785-92. Epub 2005 Jun 26.