Dr. Henry W. Strobel
The University of Texas Health Science Center at Houston
Department of Biochemistry and Molecular Biology
- Drug metabolism
- Cancer chemotherapy
- Cytochrome P-450
- Neurobiology of drug action
Our long term goal is to define the components, interaction, and regulation of the cytochrome P-450 dependent drug and carcinogen metabolism system and to describe the central role of this system in organ specific carcinogenesis and chemotherapy. We use rat liver, brain and colon, human colon, and human colon tumor cell lines as model systems in our research and we are using a variety of cDNA clones of various drug metabolism enzymes to identify those which activate carcinogens and anti-cancer agents.
A tutorial in this laboratory would give experience in physical, chemical, enzymatic or molecular biological approaches to carcinogenesis, chemotherapy and toxicology.