Dr. Lee M. Ellis
The University of Texas MD Anderson Cancer Center
Departments of Cancer Biology and Surgical Oncology
Please note: Dr. Ellis is not accepting full-time students at this time, but he will consider tutorial students
The primary objective of our research is to identify factors in the microenvironment of tumors that mediate vascular function and crosstalk with tumor cells. All of our work is in the field of gastrointestinal malignancies, with the major focus in colorectal cancer. Work from our laboratory has demonstrated that vascular endothelial growth factor (VEGF) is an important angiogenic factor in primary and metastatic human colon cancer. However, we recognize that angiogenesis is extremely complex and requires the coordinated effects of numerous factors within the microenvironment. Thus we attempt to study multiple mediators of GI cancer angiogenesis. In addition, we have found that VEGF receptors are present on tumor cells and recent work has focused on their direct role in tumor cell function. More recent studies have focused on endothelial cell to tumor cell crosstalk (angiocrine signaling). We are also establishing neuroendocrine tumor cell lines as a resource for studies identifying new targets. We have a broad interest in targeted therapies for GI malignancies and are intent on conducting clinically relevant studies that may be translated to the clinic. Other projects include investigations in cancer stem cells, EMT and miRNAs and chemoresistance.
Program in Cancer Biology
Office: MDA SRB1.123b (Unit 173)
M.D. - University of Virginia School of Medicine - 1990