Dr. Junjie Chen
The University of Texas MD Anderson Cancer Center
Department of Experimental Radiation Oncology
- Genomic instability
- DNA damage
- DNA repair
- Tumor suppressor
My research program focuses on DNA damage pathways, genomic instability and tumorigenesis. We study a number of tumor suppressors involved in DNA damage responsive pathways, including BRCA1, BRCA2, ATM, Chk2 and p53. By using biochemical, cell biology and genetic approaches, we are attempting to understand how the dysregulation of these tumor suppressors contributes to genomic instability and tumorigenesis.
A tutorial student in my laboratory would have the opportunity to work on an independent research project related to cancer biology, cell cycle regulation or aging.
Fu Z, Malureanu L, van Deursen JM, Tindall DJ*, Chen J* (*corresponding authors) (2008) Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional program required for mitotic progression. Nature Cell Biology, 10(9):1076-82.
Feng L, Huang J, Chen J (2009) MERIT40 facilitates BRCA1 localization and DNA damage repair. Genes Dev, 23(6):719-28.
Maddika S, Chen J (2009) Protein kinase DYRK2 is an E3-ligase specific molecular assembler. Nature Cell Biology, 11(4):409-19.
Huang J, Huen MS, Kim H, Leung CC, Glover JN, Yu X, Chen J (2009) RAD18 transmits DNA damage signalling to elicit homologous recombination repair. Nature Cell Biology, 11(5):592-603.