Dr. Eric J. Wagner
The University of Texas Health Science Center at Houston
Department of Biochemistry and Molecular Biology
- Cell cycle regulation of RNA processing, specifically of histone mRNA
- Biosynthesis of small nuclear RNA including the U1, U4, and U7 snRNAs
- Developmental regulation of Drosophila histone mRNA and snRNA
The research in my laboratory applies a systems biology approach of high throughput analysis using genome-wide RNA interference screening technology. We use this approach to identify novel genes involved in the regulation of histone mRNA during S phase as well as genes governing the synthesis of snRNA.
A research tutorial in my lab will allow a student to use a combination of biochemical, molecular biological, and genetic approaches in both human cells and Drosophila.
Wagner EJ, Burch BD, Godfrey A, Salzler HR, Duronio RJ, Marzluff WF (2007) A genome-wide RNA interference screen reveals that variant histones are necessary for replication-dependent histone pre-mRNA processing. Mol Cell. Nov 30;28(4):692-9.
Marzluff WF, Wagner EJ, Duronio RJ (2008) Histone mRNA metabolism: Life without a polyA Tail. Invited review at Nature Reviews Genetics. Nov;9(11):843-54.
Wagner EJ, Marzluff (2006) ZFP100 is a Limiting Component of the U7snRNP that is required for G1/S phase Transition. Mol Cell Biol. Sep;26(17):6702-12.
Program in Biochemistry and Molecular Biology