Dr. Candelaria Gomez-Manzano
The University of Texas M. D. Anderson Cancer Center
Departments of Neuro-Oncology and Cancer Genetics
- Cancer stem cells
- Brain tumors
- Tie2-multicompartmental role
- E2F pathway
The research in my laboratory is focused in understanding the cause of resistance of gliomas to therapies, and has an important translational component. Because the current tenet on brain tumor stem cells as cells responsible for the recurrence of gliomas after surgery and for the resistance of these tumors to chemotherapy and radiotherapy, the development of cancer stem cell-based tumor models will be of great utility for uncovering the molecular mechanism responsible for the resistance of malignant gliomas to conventional therapies.
Depending on the student’s interests, a tutorial in my laboratory would provide a student with the application of the scientific method and understanding cancer as a multicompartmental disease. He/she might get experience in the methodology related with the isolation and characterization of brain tumor stem cells, and experiments related to the use of transgenic animals to understand gliomagenesis.
Alonso MM, Fueyo J, Shay JW, Aldape KD, Jiang H, Lee O-K, Johnson DG, Xu J, Kondo Y, Kanzawa T, Kyo S, Bekele BN, Zhou X, Nigro J, McDonald M, Yung WKA, Gomez-Manzano C (2005) E2F1 and telomerase expression in glioblastomas: mechanistic linkage and prognostic significance. J Natl Cancer Inst;97:1589-600.
Lee O-K, Xu J, Fueyo J, Fuller G, Aldape K, Alonso MM, Piao Y, Liu T-J, Lang FF, Bekele B.Nebiyou, Gomez-Manzano C (2006) Expression of the receptor tyrosine kinase Tie2 in neoplastic glial cells is associated with integrin beta 1-dependent adhesion to extracellular matrix. Mol Cancer Res; 4:915-26.
Olson MV, Johnson DG, Jiang H, Xu J, Alonso MM, Aldape KD, Fuller GN, Bekele BN, Yung WKA, Gomez-Manzano C, Fueyo J (2007) Transgenic E2F1 expression in the mouse brain induces a human-like bimodal pattern of tumors. Cancer Res; 67:4005-9.
Lee O-H, Xu J, Fueyo J, Alonso MM, Liu D, Martin V, Jiang H, Piao Y, Liu TJ, Gomez-Manzano C (2008) Angiopoietin-2 decreases vascular endothelial growth factor expression by modulating HIF-1a levels in gliomas. Oncogene ;27:1310-4.