Dr. Shao-Cong Sun
The University of Texas MD Anderson Cancer Center
Department of Immunology
The research in our laboratory concerns signal transduction regulating immune functions, with a focus on the NF-kB pathway. NF-kB is a family of transcription factors that regulates both innate and adaptive immune responses. Deregulated activation of NF-kB or its regulatory kinases is associated with chronic inflammation, autoimmunity, and cancers. Our long-range goals are to dissect the signaling pathway mediating NF-kB activation and to elucidate the role of NF-kB in regulating normal immune response and immunological disorders. Our current studies include (1) ubiquitination and deubiquitination in the regulation of NF-kB and immune functions, (2) signaling pathways regulating immunological tolerance, autoimmunity, and chronic inflammation, (3) NF-kB and related signaling pathways involved in anti-viral and anti-bacterial innate immunity, and (4) deregulated activation of NF-kB in cancer development.
A tutorial in my laboratory will provide experience in signal transduction, innate and adaptive immune function, and cancer biology. Students will gain experimental experience in various molecular and immunological techniques, including molecular cloning, gene expression analyses, protein/protein interaction, cell culture, preparation and flow cytometric analysis of immune cells.
Office: MDA SCRB4.2019 (Unit 902)
Ph.D. - Stockholm University - 1992