Dr. Barrett R. Harvey
The University of Texas at Houston
Institute for Molecular Medicine
- Applied biologics
- Recombinant antibodies
- Directed evolution
- High throughput selections
Research in my laboratory focuses on design and development of recombinant antibodies and biologics as they relate to therapeutic, diagnostic and basic research needs. To this end, the laboratory ventures into a number of diverse biological fields including oncology, cardiology, neurology, and infectious disease. Utilizing high throughput strategies we design technology for the discovery of novel therapeutic targets, for the maturation of antibody fragments, and for de novo antibody generation. In addition we explore specific features of antibodies that make them best suited for individual applications including isotypes, affinity, epitope, half-life, stability and valency. Specific research programs include the evaluation of passive immunization strategies against gram positive pathogens, biomarker design for environmental sampling, the potency of directed cancer therapies, and the exploration of potential cardiac risk candidates as targets for recombinant antibody therapy.
A tutorial in my laboratory would provide experience in directed evolution techniques, generation and design of recombinant antibodies, in vitro assay development for high throughput selections, and general molecular biology skills.