GSBS logo
 
Degrees of Discovery logo
 
 

Dr. Nami McCarty

Dr. Nami McCarty

Regular Member

The University of Texas Health Science Center at Houston

Institute of Molecular Medicine
Centre for Stem Cell Research

Various reports have identified stem-like cells as important mediators for tumor initiation and progression in hematological cancers and solid tumors. Malignant stem-like cells have the unique ability to proliferate and self-renew extensively. However, the mechanisms of the tumor initiation and rapid growth by these cells have largely unknown. The current focus of my lab is to characterize molecular and cellular mechanisms that confer survival and drug resistance stem-like cells in various hematopoietic malignancies and how components of these pathways are functionally linked. We are currently using mantle cell lymphoma and multiple myeloma as model systems to investigate these issues.

Another project we are focusing on is how cancer cells evade the host immune functions to promote uncontrolled growth. These immune evasion phenomenons are also important in occurrence of stem cells, and understanding such mechanisms became a critical issue for stem cell related therapies. Characterizing the immune surveillance mechanisms by cancer cells and stem cells will have important translational and preclinical implications.

Research Projects

  • Investigating the roles of stem-like cells in blood cancers
  • Developing targeted therapies against signaling pathways in multiple myeloma and Non-Hodgkin’s Lymphomas
  • Characterizing the molecular and cellular mechanisms of malignant cell development and progression in blood cancers
  • Analyzing immune escape mechanisms of malignant cells in blood cancers

PubMed

SciVal

Medical School Faculty

Program Affiliations:

Clinical and Translational Sciences

Experimental Therapeutics

Immunology

Contact Information

Phone: 713.500.2495

Email: Nami.McCarty@uth.tmc.edu

Office: IMM/SRB 630H

Title: Assistant Professor

Education:

Ph.D. - Purdue University - 2000