Dr. Nami McCarty
The University of Texas Health Science Center at Houston
Institute of Molecular Medicine
Centre for Stem Cell Research
Various reports have identified stem-like cells as important mediators for tumor initiation and progression in hematological cancers and solid tumors. Malignant stem-like cells have the unique ability to proliferate and self-renew extensively. However, the mechanisms of the tumor initiation and rapid growth by these cells have largely unknown. The current focus of my lab is to characterize molecular and cellular mechanisms that confer survival and drug resistance stem-like cells in various hematopoietic malignancies and how components of these pathways are functionally linked. We are currently using mantle cell lymphoma and multiple myeloma as model systems to investigate these issues.
Another project we are focusing on is how cancer cells evade the host immune functions to promote uncontrolled growth. These immune evasion phenomenons are also important in occurrence of stem cells, and understanding such mechanisms became a critical issue for stem cell related therapies. Characterizing the immune surveillance mechanisms by cancer cells and stem cells will have important translational and preclinical implications.
- Investigating the roles of stem-like cells in blood cancers
- Developing targeted therapies against signaling pathways in multiple myeloma and Non-Hodgkin’s Lymphomas
- Characterizing the molecular and cellular mechanisms of malignant cell development and progression in blood cancers
- Analyzing immune escape mechanisms of malignant cells in blood cancers
Office: IMM/SRB 630H
Title: Assistant Professor
Ph.D. - Purdue University - 2000