Dr. Dapeng Zhou
The University of Texas MD Anderson Cancer Center
Department of Melanoma Medical Oncology/Immunology
The research in my laboratory is directed towards understanding the mechanisms by which T cells recognize antigens in cancer settings. A strong interest in our lab is to develop new candidate glycolipid drugs that stimulate and activate the immune system in cancer patients. Our current studies focus on synthetic glycolipid antigens which stimulate a unique type of T cells named as Natural Killer T (NKT) cells; natural tumor antigens which serve as targets for NKT cells; and strategies to combine the anti-cancer effect of NKT cells with other therapeutic approaches such as cancer vaccines.
Depending on the student’s interests, a tutorial in my laboratory will provide experience in generating cancer specific human T cell clones with the potential to be adoptively transferred to treat melanoma, leukemia, lymphoma and myeloma; working with mouse models of cancer and testing new drug candidates in such models; learning multiple color flow cytometry analysis with advanced instruments; and characterizing cancer antigens at the molecular level by highly quantitative and specific methods such as mass spectrometry.
Office: MDA SCR2.2015 (Unit 904)
Title: Assistant Professor
M.D./Ph.D. - University of Zurich - 2000