Dr. Gabor Balazsi
The University of Texas MD Anderson Cancer Center
Department of Systems Biology
Project #1. We study by experiment and computational modeling the combined effect of network structure on stochastic gene expression and cell population fitness. Our earlier studies proved that gene expression noise can aid survival after a single exposure to stress. The current project aims to test the effect of feedback regulation on the emergence of non-genetic drug resistance, and the evolution of genetic drug resistance.
Project #2. We are designing synthetic gene constructs to accurately control various aspects of gene expression within a cell population. For example, we can now independently adjust the mean and noise (Coefficient of Variation) of a target gene in yeast. We have also built a "linearizer" gene circuit that converts a nonlinear (sigmoidal) dose response to linear.
Project #3. We study the response of large-scale gene regulatory networks of infectious bacteria and cancer cells to various factors using microarray data. We identify distinct sets of transcriptional subnetworks that are characteristic to bacterial persistence or clinical cancer subtypes. These results will open the door for a systems-level identification of driver networks responsible for various cellular phenotypes.
Office: MDA 2SCR3.2022 (Unit 950)
Title: Associate Professor
Ph.D. - University of Missouri - St. Louis and Rolla - 2001