Dr. Lin Ji
The University of Texas MD Anderson Cancer Center
Department of Thoracic & Cardiovascular Surgery
- Functional characterization of novel tumor suppressor genes in vitro and in vivo
- Development of the recombinant adenoviral vector, non-viral vector, and nanoparticle-mediated molecular therapy for lung cancer and other human cancers
- Functional genomics and proteomics studies for characterization and identification of biomarkers and cancer signature proteins for early detection and diagnosis of lung cancer
- Development of human lung cancer mouse models for understanding lung cancer biology and evaluating cancer intervention and prevention therapeutics
Functional characterization of novel tumor suppressor genes in vitro and in vivo; development of the recombinant adenoviral vector, non-viral vector, and nanoparticle-mediated molecular therapy for lung cancer and other human cancers; functional genomics and proteomics studies for characterization and identification of biomarkers and cancer signature proteins for early detection and diagnosis of lung cancer; development of human lung cancer mouse models for understanding lung cancer biology and evaluating cancer intervention and prevention therapeutics.
The research in my laboratory is focused on understanding the molecular mechanisms of novel tumor suppressor genes especially those recently identified in human chromosome 3p21.3 region where the genomic and genetic abnormalities are frequently found in a wide spectrum of human cancers including lung and breast cancers and exploring their therapeutic applications for human cancers by recombinant adenoviral vector, non-viral vector, and nanoparticle-mediated gene transfer in vitro, in animal models, and in human clinical trials. We are also interested in using the high throughput functional genomics and proteomics approaches such as gene microarrays, tissue microarrays, and ProteinChip arrays to identify biomarkers and signature proteins involved in oncogenic and tumor suppressing signaling pathways, to study posttranslational modifications such as phosphorylation and glycosylation of proteins as well as protein-protein interactions in human cancers, particularly, in lung cancer. Our research activities also emphasize in understanding the mechanisms of drug resistance and exploring combination treatment strategies for overcoming the drug resistance. We are also developing various human lung cancer xenograft and transgenic mouse models to understand the biology of lung cancer pathogenesis and to evaluate novel cancer therapeutic strategies and agents.
Depending on the student's interests, a tutorial in my laboratory would provide experience with cancer biology, tumor suppressor function, cancer gene therapy, functional genomics and proteomics, nanotechnology for anti-cancer drug and gene delivery, molecular imaging, transgenic mouse models, as well as basic biochemical, molecular cloning and biology methods and technologies.
Otani S, Iwamaru A, Deng W, Ueda K, Wu G, Jayachandran G, Kondo S, Atkinson EN, Minna JD, Roth JA, Ji L. Tumor suppressor 101F6 and ascorbate synergistically and selectively inhibit non-small cell lung cancer growth by caspase-independent apoptosis and autophagy. Cancer Res 67:6293-6303, 2007.
Deng WG, Jayachandran G, Wu G, Xu K, Roth JA, Ji L. Tumor-specific activation of human telomerase reverses transcriptase promoter activity by activating enhancer-binding protein-2β in human lung cancer cells. J Biol Chem 282:26460-26470, 2007.
Jayachandran G, Sazaki J, Nishizaki M, Xu K, Girard L, Minna JD, Roth JA, Ji L. Fragile histidine triad-mediated tumor suppression of lung cancer by targeting multiple components of the Ras/Rho GTPhase molecular switch. Cancer Res 67:10379-88, 2007.
Ji, L., and Roth, J.A. Tumor suppressor FUS1 signaling pathway. J Thorac Oncol 3:327-330, 2008.
Jayachandran G, Ueda K, Wang B, Roth JA, Ji L. NPRL2 Sensitizes Human Non-Small Cell Lung Cancer (NSCLC) Cells to Cisplatin Treatment by Regulating Key Components in the DNA Repair Pathway. PLoS One 5(8):e11994, 2010.
Lin J., Xu K., Jayachandran G., Roth JA, and Ji L, Regulation of tumor suppressor gene FUS1 expression by the untranslated regions of mRNA in human lung cancer cells. Biochem. Biophys. Res. Comm., 410: 235-241, 2011.
Office: MDA FCT19.5078 (Unit 445)
Title: Associate Professor
Ph.D. - University of Nebraska-Lincoln - 1993