Dr. Randa El-Zein
The University of Texas MD Anderson Cancer Center
Department of Epidemiology
My research interests focus on understanding the role of gene-environment interactions and the modifying effects on the risk for development of cancer. Studies conducted integrate several endpoints that specifically measure levels of genetic instability induced by such interactions. In addition such endpoints are selected in a manner to allow a better understanding of the different mechanisms involved in the generated genetic instability (whether it is due to accumulated DNA damage, inhibition of apoptosis, specific mutations or cell arrests).
The ultimate goal of my research in the next few years is to develop approaches to identify individuals at high risk of developing adverse health effects due to being genetically susceptible to certain environmental insults. Such susceptible subgroups may benefit tremendously from screening or chemoprevention interventions. In addition, studies in these high-risk individuals will provide insight into applying these approaches to the average risk population.
Depending on the student’s interests, a tutorial in my laboratory would provide experience with molecular epidemiological approaches, conventional and molecular cytogenetic methods, determining DNA damage/ repair capacity using novel phenotypic assays.
Office: MDA CPB3478 (Unit 1340)
Title: Associate Professor
M.D. - Alexandria University - 1984
Ph.D. - The University of Texas Medical Branch at Galveston- 1997