Dr. Yu Shen

Regular Member

The University of Texas MD Anderson Cancer Center
Department of Biostatistics and Applied Mathematics

Research Interests:

• Design and analysis of clinical trials
• Modeling dynamic process of cancer screening procedure
• Survival analysis
• Estimation of natural history of diseases

The long term objective of my research is to develop statistical tools to better understand the nature of cancer prevention trials, and to design efficient clinical trials, and to analyze complex censored survival data from medical studies. My current areas of research include: 1) development of statistical models to evaluate early efficacy of cancer screening technologies, to better understand the dynamic nature of the cancer screening procedure, and to assess the long term survival benefit due to screening; 2) proposing new sequential monitoring methods, whereby the sample size can be sequentially determined by examining the accumulated data; 3) to develop statistical methods for complex censored survival data.

A tutorial in our laboratory would provide advanced training in statistical analysis, mathematical modeling, and computer programming.


Selected Publications:

Shen, Y, and Cheng, Y (2007) Adaptive Design: Estimation and Inference with Censored Survival Data under Proportional Hazards Model. Biostatistics, 8: 306-322.

Shen, Y, Dong, W, Esteva, FJ, Kau, S, Theriault, RL and Bevers, T (2007) Are there racial differences in breast cancer treatments and clinical outcomes for women treated at M. D. Anderson Cancer Center? Breast Cancer Research and Treatment, 102: 347-356.

Cong, X, Yin, G, and Shen, Y (2007) Marginal Analysis of Correlated Failure Time Data with Informative Cluster Sizes. Biometrics, 63: 663-672.

Shen, Y, Qin, J, and Costantino, JP (2007) Inference of Tamoxifen's Effects on Prevention of Breast Cancer from a Randomized Controlled Trial. JASA, 102: 1235-1244, 2007.

Additional Publications

Program Affiliation:

Program in Biomathematics and Biostatistics