Dr. Bingliang Fang
The University of Texas MD Anderson Cancer Center
Department of Thoracic and Cardiovascular Surgery
- Tumor specific transgene expression
- Apoptotic genes
- Cancer gene therapy
My laboratory is interested in innovative anticancer agents, targeted cancer therapy, the mechanisms of action of and/or resistance to anticancer agents, and molecular signatures or biomarkers for predicting treatment response or early diagnosis of lung cancers. Current study includes TRAIL-armed oncolyticadenovirotherapy, small molecules targeted to K-Ras and the C-terminal domain of RNA polymerase II, biomarkers in primary lung cancer, and molecular signatures of response to targeted therapy in lung cancer. Our long term goal is to develop pathway-targeted therapeutic agents that are minimally toxic and highly effective to treat refractory tumors and identify molecular signatures for predicting response or early diagnosis.
Depending on the student's interests, tutorial in my laboratory would provide experience in basic molecular biology, in vitro and in vivo tumor models, cell signaling and experimental therapy for cancer.
Guo W, Wu S, Liu J, Fang B. Identification of a small molecule with synthetic lethality for K-Ras and protein kinase Ciota (PKC). Cancer Res., 68:7403-8;2008
Guo W, Wu S, Wang L, Wang R-Y, Wei X, Liu J, Fang B. Interruption of RNA processing machinery by a small compound 1-[(4-chlorophenyl) methyl]-1H-indole-3-carboxaldehyde (oncrasin-1). Mol Cancer Ther 8:441-448;2009
Wei X, Guo W, Wu S, Wang L, Lu Y, Xu B, Liu J, Fang B. Inhibiting JNK Dephosphorylation and Induction of Apoptosis by Novel Anticancer Agent NSC-741909 in Cancer Cells. J BiolChem 284:16948-16955; 2009
Wei X, Guo W, Wu S, Wang L, Huang P, Liu J, Fang B. Oxidative stress in NSC-741909-induced apoptosis of cancer cells. J Translation Med, 8:37, 2010
Guo W, Wei X, Wu S, Wang L, Peng H, Wang J, Fang B. Antagonistic effect of flavonoids on NSC-741909-mediated antitumor activity via scavenging of reactive oxygen species. Eur J Pharm, 649:51-8; 2010
Wu S, Wang L, Guo W, Liu X, Liu J, Wei X, Fang B. Analogues and Derivatives of Oncrasin-1, a Novel Inhibitor of the C-Terminal Domain of RNA Polymerase II and Their Antitumor Activities. J Med Chem. 54:2668-2679, 2011.
Program in Cancer Biology
Office: MDA FCT 19.5802 (Unit 1489)
Title: Associate Professor
M.D. - Zhejiang Medical University - 1982
Ph.D. - Hamburg University - 1989