Dr. Stanley R. Hamilton
The University of Texas MD Anderson Cancer Center
Department of Pathology
Our laboratory research investigates molecular genetics and genomics of gastrointestinal neoplasia with emphasis on translational applications to the management of patients with GI cancer. Our multidisciplinary research activities focus on two main areas: 1) Identification and application of molecular markers for prognosis of gastrointestinal adenocarcinomas and for prediction of response to therapy. 2) The etiology and molecular pathogenesis of colorectal neoplasia.
We study the relationship of molecular markers in tumors to survival of patients in clinical trials. These correlative laboratory studies are directed mainly at colorectal adenocarcinoma. Discovery of new markers is based on application of genomics and molecular genetics to determine the abnormalities in genes and gene expression responsible for the molecular subtypes of colorectal cancers, especially in relation to their biological behavior.
We also carry out molecular pathology studies to identify environmental, especially dietary, factors that can be related to molecular genetic abnormalities in colorectal cancer and its precursors. These investigations include studies of specimens from patients in clinical trials of chemopreventive agents incorporating epidemiologic data and international studies of tumors from patient populations with low rates of colorectal cancer for comparison to the high-incidence population in the United States.
A tutorial in our laboratory will provide experience with genetic analyses with a variety of methodologies, immunohistochemistry and western blots, tissue micro-arrays, sequencing, and translational studies using human tumor specimens and clinical data.
Office: MDA G1.3540 (Unit 85)
M.D. - Indiana University School of Medicine - 1973