Dr. Khandan Keyomarsi
The University of Texas MD Anderson Cancer Center
Department of Experimental Radiation Oncology
The research in my laboratory is focused on the development of novel strategies for treatment and prognosis of breast cancer by combining experimental therapeutics with cell biology while targeting the cell cycle. To this end, the laboratory is currently involved in 5 areas of research, which fall into translational and basic research categories:
- Investigation of the low-molecular-weight (LMW) forms of cyclin E as prognostic markers in breast cancer for routine use in the clinic.
- Delineation of how the alteration of cyclin E, a G 1 cyclin, could lead to the tumorigenic phenotype and determination of the oncogenic potential of the altered forms of cyclin E in breast cancer.
- Inhibition of LMW forms of cyclin E as a therapeutic target.
- Examination of the in vivo and subsequent clinical feasibility of a novel treatment strategy (i.e., a protection strategy) designed to protect normal proliferating cells against the toxic effects of chemotherapeutic agents.
- Determination of whether the proteasome is the target of G 1 arrest/growth inhibition mediated by farnesyl-transferase inhibitors and structurally related compounds.
A tutorial in my laboratory will provide experience with cell biology of breast cancer cells including culturing normal and tumor-derived breast cell, transfection and immunohistochemistry. Experience with molecular biology techniques (cloning, RNA and genomic DNA analysis), protein chemistry (purification of proteins interacting with cyclin E in normal and tumor cells), and experimental therapeutics (treatment of normal and tumor cells with novel agents targeting the cell cycle) will also be gained. The tutorial will also help the student gain an understanding on how research can be translated from the bench to the clinic.
Office: MDA Y3.5314a (Unit 66)
Ph.D. - University of Southern California - 1989