Dr. Jeffrey J. Molldrem
The University of Texas M. D. Anderson Cancer Center
Department of Stem Cell Transplantation-Research
- Tumor immunity
- Transplant immunology
- T cell tolerance mechanisms
The research in my laboratory is primarily directed at discovering how T cells target and interact with hematopoietic tumors and normal hematopoietic progenitors, and at understanding how immune tolerance develops to hematopoietic cells. A strong interest in our lab is the discovery of novel tumor antigens and translating new immunotherapeutic approaches to the clinical situation. Current studies in our lab focus on MHC class-restricted epitopes in leukemia cells, how cytotoxic T lymphocytes are tolerized to those epitopes, mechanisms of regulation of leukemia antigen genes.
Depending on the student's interests, a tutorial in my laboratory would provide experience with human T cell cloning techniques, cytotoxicity and proliferation assays, MHC tetramer constructs and analysis, basic DNA cloning methods, and transfection of newly-identified tumor antigens into antigen presenting cells.
Program in Immunology
Office: MDA SCR3.3011 (Unit 900)
M.D. - University of Minnesota - 1990