Dr. Yahuan Lou
The University of Texas Health Science Center at Houston
School of Dentistry
Department of Diagnostic Science
- Immune tolerance
- Cellular immunology: animal models
The research in my laboratory is directed at understanding cellular and molecular mechanisms that initiate human autoimmune diseases using animal models. Presently, our studies focus on three areas of investigation: 1) elucidating peripheral tolerance mechanism, which is mediated by a specialized type of dendritic cells; 2) mapping gene or genes that are involved in the maintenance of peripheral tolerance; 3) investigating the role of interactions between immune cells and the ovarian environment in ovarian function.
A tutorial in my laboratory will provide an emphasis on immunology and autoimmune diseases. Students will have a hands-on experience with modern techniques such as cell culture, flow cytometry, basic cloning methods, microarray, mouse handling and the production of a transgenic mouse.
Arends J, J Wu, J Borillo, L Truong, C Zhou, N Vigneswaran, Y-H Lou (2006) T cell epitope mimicry in anti-glomerular basement membrane disease. J. Immunol. 176 (2): 1252-1258.
Wu J, J Arends, J Borillo, C Zhou, J Merszei, J McMahon, Y-H Lou (2004) A self T cell epitope induces autoantibody response: mechanism for production of antibodies to diverse glomerular basement membrane antigens. J. Immunol. 172(4):4567-4574.
Wu J, J Hicks, J Borillo, WF Glass II, Y-H Lou (2002) CD4 + T cells specific to glomerular basement membrane antigen induce glomerulonephritis. J. Clin. Invest. 109(4)517-524.
Program in Immunology
Office: BBSB 5326
Ph.D. - Hokkaido University - 1990