Dr. Jill M. Schumacher
Our research is focused on the regulation of chromosome and microtubule dynamics during the eukaryotic cell cycle. For these studies, we utilize genetic, biochemical and cell biological methods using the soil nematode C. elegans as a model system. We have concentrated our efforts on identifying the activators, substrates, and effectors of the highly conserved Aurora and Tousled-like kinase families and deciphering their functional roles in mitotic spindle assembly, chromosome segregation, and cell cycle progression. We have recently begun to translate our findings in C. elegans to the role of these proteins in the etiology of breast and ovarian cancer. Our goal is to identify novel prognostic markers that will delineate ovarian and breast tumor sub-types and to elucidate the effect of these proteins on the sensitivity of cancer cells to clinically-relevant spindle poisons and DNA damaging agents (i.e., Cisplatin and Paclitaxel).
Program in Genes and Development
Office: MDA BSRB S11.8136C (Unit 1010)
Title: Associate Professor
Ph.D. - University of Washington - 1995