Dr. Ba-Bie Teng
The University of Texas Health Science Center at Houston
Department of Research Center for Human Genetics
Institute of Molecular Medicine
Dr. Teng's laboratory is interested in the discovery of mechanisms contributing to the complex process of atherosclerosis in humans and animal models and to design and develop genetic and cell therapies for the treatment of atherosclerotic vascular disease.
Techniques to learn in a tutorial:
Structure biology: design ribozymes and miRNA, vaccine development, study protein-protein interaction
Molecular biology: cloning and construction of viral vectors
Viral vector delivery: adeno-associated viral vectors and lentiviral vectors
Biochemical assays: HPLC, FPLC, ELISA, and Western Blot analysis
Biological evaluation: cell culture, animal models
Bioinformatics on miRNA
Mouse physiology and biology
Ranjan Dutta, Uma Singh, Tong-Bin Li, Myriam Fornage, Teng BB (2003) Hepatic Gene Expression Profiling Reveals Perturbed Calcium Signaling in a Mouse Model Lacking Both LDL Receptor and Apobec1 Genes. Atherosclerosis. 169: 51-62.
Uma Singh, Shumei Zhong, Momiao Xiong, Tong-bin Li, Allan Sniderman, Teng BB (2004) Increased plasma nonesterified fatty acids and platelet-activating factor acetylhydrolase are associated with susceptibility to atherosclerosis in mice. Clinical Science. 106: 421-432.
Shumei Zhong, Shihua Sun, Teng BB (2004) The recombinant adeno-associated virus vector (rAAV2)-mediated apolipoprotein B mRNA-specific hammerhead ribozyme: a self-complementary rAAV2 vector improves the gene expression.,i>Genetic Vaccines and Therapy 2: 5.
Shumei Zhong, Chichi Liu, David Haviland, Peter A. Doris, Teng BB (2006) Simultaneous Expression of Apolipoprotein B mRNA Editing Enzyme and Scavenger Receptor BI Mediated by a Therapeutic Gene Expression System. Atherosclerosis. 184: 264-275.
Solida Mak, Hua Sun, Frances Acevado, Lawrence Shimmin, Lei Zhao, Ba-Bie Teng*, and James Hixson (2010): Differential expression of genes in calcium signaling pathway underlies lesion development in the LDb mouse model of atherosclerosis. (*corresponding author) Atherosclerothesis. 213: 40-51
Office: IMM SRB 530D
Title: Associate Professor
Ph.D. - McGill University - 1987