Dr. Stephanie S. Watowich
The University of Texas MD Anderson Cancer Center
Department of Immunology
- Cytokine receptors
- Cell proliferation and differentiation
- Signal transduction
The goal of my research is to understand the molecular mechanisms that control the development and function of immune cells, with particular emphasis on the role that cytokines play in immunity. We use in vivo model systems to examine the biological function of cytokine signaling intermediates in the STAT transcription factor family within the immune system. A tutorial in my laboratory will provide experience in current immunological and molecular biology techniques. More importantly, the tutorial will focus on learning to think independently and to choose exciting, and medically relevant research projects.
Nguyen-Jackson H, Panopoulos AD, Zhang H, Li HS, Watowich SS. STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction. Blood, 115(16):3354-63, 2010. e-Pub 2/25/2010. PMIF: 30286685
Zhang H, Nguyen-Jackson H, Panopoulos AD, Li HS, Murray PJ, Watowich SS. STAT3 controls myeloid progenitor growth during emergency granulopoiesis. Blood, 116:2462-71, 2010, PMID: 20581311 (featured in Research Highlights, Nat Immunol, 11:689, 2010)
Watowich SS, Liu YJ. Mechanisms regulating dendritic cell specification and development. Immunol Rev. 238:76-92, 2010.
Li HS, Geibard A, Martinez G, Esashi E, Zhang H, Nguyen-Jackson H, Liu YJ, Overwijk WW, Watowich SS. Cell intrinsic role for interferon-α-STAT1 in regulating murine Peyer's Patch plasmacytoid dendritic cells and conditioning an inflammatory response. Blood 118(14):3879-89, 2011. PMID: 21828128
Yang CY, Best JA, Knell J, Yang E, Sheridan AD, Jesionek AK, Li HS, Rivera RR, D'Cruz LM, Watowich SS, Murre C, Goldrath AW. Transcriptional regulators Id2 and Id3 control formation of distinct CD8+ memory T cell subsets. Nat Immunol. 12(12):1221-9. 2011. PMID: 22057289
Office: MDA SCR4.3023 (Unit 902)
Title: Associate Professor
Ph.D. - Northwestern University - 1990