Dr. Elizabeth L. Travis
The University of Texas MD Anderson Cancer Center
Department of Experimental Radiation Oncology
- Radiation-induced fibrosis
- Genetic basis of tissue radiation sensitivity and fibrosis
- Growth factors
The goal of this work is to understand the mechanisms and pathogenesis of tissue damage, repair, and remodeling (fibrosis) after treatment with radiation or chemotherapeutic agents. One project in the lab involves investigating the genetic basis of radiation or drug-induced fibrosis in a number of normal tissues, including the lung, colon, and kidney, using murine models with varying susceptibilities to these agents. Another project is investigating the role of growth factors in tissue fibrosis.
A tutorial in this laboratory may include genotyping (PCR) and phenotyping mice to establish linkage between genomic markers and the fibrotic phenotype, determination of the radiation- or drug-induced expression of cytokine protein using western blot or ELISA, or mRNA using northern or RT-PCR analysis and immunohistochemical localization of TGF-beta in treated tissues.
Program in Experimental Therapeutics
Office: MDA (Unit 1413)
Ph.D. - University of South Carolina - 1976