Dr. James M. Reuben

Regular Member

The University of Texas MD Anderson Cancer Center
Department of Hematopathology Research

Research Interests:

• Acquired immunodeficiency syndrome (AIDS)
• Cellular immunology
• cytokinesCSerology
• Cytotoxicity: NK, ADCC, CTL, LAK

AIDS in children is most frequently acquired by vertical transmission; approximately 30% of infants born to HIV-infected mothers eventually succumb to infection by this virus. It is unclear whether infection occurs most frequently in utero or intrapartum. Our research involves identifying host factors that are likely to enhance transmission of maternal leukocytes across vascular endothelial barriers and/or affect the ability of the placenta to impair transmission of virus from mother to fetus. We are interested in determining a) whether placental cells are producing virus or whether the virus remains latent in these cells, such that various activators are needed to stimulate replication; b) functional properties of the placental cells and maternal leukocytes that facilitate or bar transmission of the virus across the placental barrier.

A tutorial in my laboratory will provide experience in identifying placental leukocytes by immunophenotype using flow cytometry; quantitative measurement of message, production of cytokines and associated receptor assays; HIV serology, and cellular cytotoxicity.

Selected Publications:

De Giorgi U, Valero V, Rohren E, Mego M, Doyle GV, Miller MC, Ueno NT, Handy BC, Reuben JM, Macapinlac HA, Hortobagyi GN, Cristofanilli M. Circulating tumor cells and bone metastases as detected by FDG-PET/CT in patients with metastatic breast cancer. Ann Oncol 21(1):33-9, 1/2010. e-Pub 7/14/2009. PMID: 19602564.

Mego M, De Giorgi U, Broglio K, Dawood S, Valero V, Andreopoulou E, Handy B, Reuben JM, Cristofanilli M. Circulating tumour cells are associated with increased risk of venous thromboembolism in metastatic breast cancer patients. Br J Cancer 101(11):1813-6, 12/1/2009. e-Pub 11/3/2009. PMCID: PMC2788266.

Mego M, De Giorgi U, Hsu L, Ueno NT, Valero V, Jackson S, Andreopoulou E, Kau SW, Reuben JM, Cristofanilli M. Circulating tumor cells in metastatic Inflammatory Breast Cancer. Ann Oncol 20(11):1824-8, 11/2009. e-Pub 6/25/2009. PMID: 19556320.

Jain N, Reuben JM, Kantarjian H, Li C, Gao H, Lee BN, Cohen EN, Ebarb T, Scheinberg DA, Cortes J. Synthetic tumor-specific breakpoint peptide vaccine in patients with chronic myeloid leukemia and minimal residual disease: a Phase 2 Trial. Cancer 115(17):3924-34, 9/2009. e-Pub 6/2009. PMID: 19536894.

De Giorgi U, Valero V, Rohren E, Dawood S, Ueno NT, Miller MC, Doyle GV, Jackson S, Andreopoulou E, Handy BC, Reuben JM, Fritsche HA, Macapinlac HA, Hortobagyi GN, Cristofanilli M. Circulating Tumor Cells and [18F]Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography for Outcome Prediction in Metastatic Breast Cancer. J Clin Oncol 27(20):3303-11, 7/10/2009. e-Pub 5/18/2009. PMID: 19451443.

Lu J, Steeg PS, Price JE, Krishnamurthy S, Mani SA, Reuben J, Cristofanilli M, Dontu G, Bidaut L, Valero V, Hortobagyi GN, Yu D. Breast cancer metastasis: challenges and opportunities. Cancer Res 69(12). e-Pub 5/2009. PMID: 19470768.

Shearer WT, Ochs HD, Lee BN, Cohen EN, Reuben JM, Cheng I, Thompson B, Butel JS, Blancher A, Abbal M, Aviles H, Sonnenfeld G. Immune responses in adult female volunteers during the bed-rest model of spaceflight: Antibodies and cytokines. J Allergy Clin Immunol 123(4):900-5, 4/2009. e-Pub 2/2009. PMID: 19232702.

Cristofanilli M, Krishnamurthy S, Das CM, Reuben JM, Spohn W, Noshari J, Becker F, Gascoyne PR. Dielectric cell separation of fine needle aspirates from tumor xenografts. J Sep Sci 31(21):3732-9, 12/2008. PMID: 18958846.

Dawood S, Broglio K, Valero V, Reuben J, Handy B, Islam R, Jackson S, Hortobagyi GN, Fritsche H, Cristofanilli M. Circulating tumor cells in metastatic breast cancer: from prognostic stratification to modification of the staging system? Cancer 113(9):2422-30, 11/2008. PMID: 18785255.

Wang XS, Shi Q, Williams LA, Cleeland CS, Mobley GM, Reuben JM, Lee BN, Giralt SA. Serum interleukin-6 predicts the development of multiple symptoms at nadir of allogeneic hematopoietic stem cell transplantation. Cancer 113(8):2102-9, 9/2008. PMCID: PMC2633777.

Cristofanilli M, Reuben J, Uhr J. Circulating tumor cells in breast cancer: fiction or reality? J Clin Oncol 26(21):3656-7, 7/2008. PMID: 18640950.

Lucci A, Krishnamurthy S, Singh B, Bedrosian I, Meric-Bernstam F, Reuben J, Broglio K, Mosalpuria K, Lodhi A, Vincent L, Cristofanilli M. Cylooxygenase-2 expression in primary breast cancers predicts dissemination of cancer cells to the bone marrow. Breast Cancer Res Treat, 7/2008. e-Pub 7/2008. PMID: 18663571.

Publications