Dr. James M. Reuben
The University of Texas MD Anderson Cancer Center
Department of Hematopathology Research
AIDS in children is most frequently acquired by vertical transmission; approximately 30% of infants born to HIV-infected mothers eventually succumb to infection by this virus. It is unclear whether infection occurs most frequently in utero or intrapartum. Our research involves identifying host factors that are likely to enhance transmission of maternal leukocytes across vascular endothelial barriers and/or affect the ability of the placenta to impair transmission of virus from mother to fetus. We are interested in determining a) whether placental cells are producing virus or whether the virus remains latent in these cells, such that various activators are needed to stimulate replication; b) functional properties of the placental cells and maternal leukocytes that facilitate or bar transmission of the virus across the placental barrier.
A tutorial in my laboratory will provide experience in identifying placental leukocytes by immunophenotype using flow cytometry; quantitative measurement of message, production of cytokines and associated receptor assays; HIV serology, and cellular cytotoxicity.
Office: MDA T8.3908 (Unit 54)
Title: Associate Professor
Ph.D. - McGill University - 1979