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Dr. Hope Northrup

Dr. Hope Northrup

Regular Member

The University of Texas Health Science Center at Houston
Medical School
Department of Pediatrics

Research in my laboratory focuses on two disorders: tuberous sclerosis complex (TSC) and spina bifida cystica. TSC is inherited in an autosomal dominant fashion with two known genes on chromosome 9q34.3 (TSC1) and on chromosome 16p13.3 (TSC2) for the TSC phenotype. Current work underway includes mutational analysis and functional studies of both genes. The spina bifida project is using a candidate gene approach to search for genetic associations.

A tutorial in my laboratory will expose the student to common molecular genetic techniques including subcloning, DNA sequencing, Southern blot analysis, single strand conformational polymorphic analysis, cell free transcription-translation, protein-protein interaction techniques, Western blotting and immunoprecipitation.

PubMed

SciVal

Medical School Faculty

Program Affiliations:

Program in Genetic Counseling

Program in Human and Molecular Genetics

Contact Information

Phone: 713.500.5760

Email: Hope.Northrup@uth.tmc.edu

Office: MSB 3.144

Title: Professor

Education:

M.D. - Medical University of South Carolina - 1983