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Dr. Michael C. MacLeod

Dr. Michael C. MacLeod

Distinguished Senior Lecturer

The University of Texas MD Anderson Cancer Center
Department of Molecular Carcinogenesis
The Virginia Harris Cockrell Cancer Research Center

My laboratory is located in Smithville, Texas, at UT Science Park

We have recently discovered that the ATF3 gene, coding for a member of the bZip transcription factor family, acts as an oncogene in transgenic mice, producing tumors of the oral epithelium and of the mammary gland. Current work in the lab focuses on the mechanism of ATF3 action in these transgenic mice, particularly on possible effects on the Wnt/beta-catenin signaling pathway. In an unrelated project, we are involved in an NIH sponsored counter-terrorism consortium developing treatments for chemical threat agents that might be employed by terrorists in this country. A previously developed cancer chemopreventive agent, 2,6-dithiopurine, is being studied as an effective scavenging agent against sulfur mustard gas, which is itself a powerful toxicant as well as a carcinogen.

 

PubMed

MDACC Faculty

Program Affiliation:

Program in Molecular Carcinogenesis

Contact Information

Phone: 512.237.9541

Email: mcmacleod@mdanderson.org

Office: MDA SPRD SRM 1.210 (Unit 116)

Title: Professor

Education:

Ph.D. - University of Oregon - 1974