Dr. Michael C. MacLeod
Distinguished Senior Lecturer
The University of Texas MD Anderson Cancer Center
Department of Molecular Carcinogenesis
The Virginia Harris Cockrell Cancer Research Center
My laboratory is located in Smithville, Texas, at UT Science Park
Research Interests:
- Chemical carcinogenesis
- Breast cancer
- DNA damage responses
- Mustard gas
We have recently discovered that the ATF3 gene, coding for a member of the bZip transcription factor family, acts as an oncogene in transgenic mice, producing tumors of the oral epithelium and of the mammary gland. Current work in the lab focuses on the mechanism of ATF3 action in these transgenic mice, particularly on possible effects on the Wnt/beta-catenin signaling pathway. In an unrelated project, we are involved in an NIH sponsored counter-terrorism consortium developing treatments for chemical threat agents that might be employed by terrorists in this country. A previously developed cancer chemopreventive agent, 2,6-dithiopurine, is being studied as an effective scavenging agent against sulfur mustard gas, which is itself a powerful toxicant as well as a carcinogen.
Program Affiliation:
Program in Molecular Carcinogenesis
Contact Information
Phone: 512.237.9541
Email: mcmacleod@mdanderson.org
Office: MDA SPRD SRM 1.210 (Unit 116)
Title: Professor
Education:
Ph.D. - University of Oregon - 1974
