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Dr. David S. Loose

Dr. David S. Loose

Regular Member

The University of Texas Health Science Center at Houston
Medical School
Department of Integrative Biology and Pharmacology

We utilize several model systems to investigate regulation of gene expression. Two of the genes we have been concentrating on are phosphenolpyruvate carboxykinase, an enzyme crucial for glucose homeostasis and c-fos, a protooncogene which is a component of a transcriptional activator. Both of these genes are regulated by steroid hormones and our goal is to study the mechanisms underlying this regulation. We have also characterized a strain of rabbits which are completely resistant to elevations in plasma cholesterol following ingestion of diets high in fats and cholesterol. We are actively pursuing the metabolic, biochemical and genetic basis of the resistant phenotype.



Medical School Faculty

Program Affiliation:

Program in Cell and Regulatory Biology (Pharmacology Track)

Contact Information

Phone: 713.500.7440


Office: MSB 4.130

Title: Associate Professor


Ph.D. - Stanford University - 1982