Dr. Julia E. Lever
Regular Member
The University of Texas at Houston Houston Medical School
Department of Biochemistry and Molecular Biology
Research Interests:
- Post-transcriptional regulation of epithelial cell differentiation
We are using a renal cell culture model system to investigate mechanisms of gene regulation and epithelial cell differentiation. We have identified several inducers which trigger a defined differentiation pathway and are exploring intracellular signaling events which mediate these responses. Currently we are focusing on the role of message stabilization in maintenance of the differentiated phenotype. We have identified several RNA-binding proteins which bind and stabilize an mRNA transcript encoding an important differentiated function. We have also identified the cognate sequences in the RNA transcript recognized by these binding proteins. Our results indicate that activation of these RNA-binding activities requires phosphorylation by protein kinases.
Publications
Program Affiliation:
Program in Biochemistry and Molecular Biology
Contact Information
Phone: 713.500.6055
Email: Julia.E.Lever@uth.tmc.edu
Office: MSB 6.201
Title: Professor
Education:
Ph.D. - University of California-Berkeley - 1971
