Dr. Julia E. Lever
The University of Texas at Houston Houston Medical School
Department of Biochemistry and Molecular Biology
- Post-transcriptional regulation of epithelial cell differentiation
We are using a renal cell culture model system to investigate mechanisms of gene regulation and epithelial cell differentiation. We have identified several inducers which trigger a defined differentiation pathway and are exploring intracellular signaling events which mediate these responses. Currently we are focusing on the role of message stabilization in maintenance of the differentiated phenotype. We have identified several RNA-binding proteins which bind and stabilize an mRNA transcript encoding an important differentiated function. We have also identified the cognate sequences in the RNA transcript recognized by these binding proteins. Our results indicate that activation of these RNA-binding activities requires phosphorylation by protein kinases.
Program in Biochemistry and Molecular Biology
Office: MSB 6.201
Ph.D. - University of California-Berkeley - 1971