Dr. M. Tien Kuo
Regular Member
The University of Texas MD Anderson Cancer Center
Department of Molecular Pathology
Research Interests:
- Mechanism of drug resistance in cancer chemotherapy
- Gene/protein therapy to liver cancer and hepatitis
- Deregulation mechanism of genomic stability in cancers
Our laboratory has three research programs: (i) oxidative stress manifested by the generation of reactive oxygen species is associated with many forms of cancer. It also regulates drug resistance in cancer chemotherapy. Enhanced antioxidant production plays an important role in the control of carcinogenesis and the development of drug resistance. Regulation of physiological antioxidant production during neoplastic transformation and development of drug resistance is being studied. (ii) A patented novel ligand derived from malaria parasite has been under development as a hepatic gene/protein delivery vector to the treatment of liver disease. (iii) A new gene whose expression is inversely correlated with genomic instability has recently been discovered in our laboratory. The control mechanism of genomic instability exerted by this gene is being studied.
Selected Publications
Contact Information
Phone: 713.834.6038
Email: tkuo@mdanderson.org
Office: MDA 2SCR4.3025 (Unit 951)
Title: Professor
Education:
Ph.D. - The University of Texas Graduate School of Biomedical Sciences at Houston - 1973
