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Dr. Richard J. Kulmacz

Dr. Richard J. Kulmacz

Regular Member

The University of Texas Health Science Center at Houston
Medical School
Department of Internal Medicine

The general goal of my lab is to characterize the mechanisms, regulation, and pharmacology of two distinct groups of membrane proteins: prostanoid biosynthetic enzymes and cytochrome b561 family members. One current focus is on prostaglandin H synthase-2, an enzyme with important roles in inflammation, carcinogenesis, wound healing, and reproductive function. This enzyme is regulated by reactive oxygen species, and it is the target of an exciting new class of non-steroidal anti-inflammatory (and potentially anti-carcinogenic) drugs. Our second current focus is on adrenal cytochrome b561, which is required for biosynthesis of catecholamine neurotransmitters, and on other members of the cytochrome b561 family whose functions are being investigated.  Our general approach is to use biochemical and biophysical characterization of native proteins and specific mutants to study the relationship between protein structure and catalytic function. 

A tutorial rotation in the lab offers the opportunity to use a variety of molecular, biochemical, spectroscopic, and kinetic techniques to better understand the ways the structure of these proteins influences their participation in health and disease processes.

PubMed

SciVal

Medical School Faculty

Program Affiliations:

Program in Biochemistry and Molecular Biology



Contact Information

Phone: 713.500.6772

Email: Richard.J.Kulmacz@uth.tmc.edu

Office: MSB 5.288

Title: Professor

Education:

Ph.D. - Rice University - 1978