Dr. Gary E. Gallick
The University of Texas MD Anderson Cancer Center
Department of Genitourinary Medical Oncology Research
- Growth factor receptors
- Tumor progression
- Molecular biology
- Colorectal carcinoma
- Squamous cell carcinoma
The goal of research in my laboratory is an understanding of the role of protein tyrosine kinases in promoting cellular survival and angiogenesis, and the result of aberrant activation of these enzymes on tumor progression and metastasis. Currently, we are studying the role of activation of two of these enzymes, Src and FAK, in prostate, colon, and ovarian carcinomas. In model tissue culture cell lines and animal studies, we have established that these enzymes regulate expression of vascular endothelial growth factor and inhibit a form of apoptosis. Using molecular and biochemical techniques, we are dissecting the signal transduction pathways responsible for these critical events in tumor progression. We are also involved in identifying tyrosine kinase targets for development of therapeutic agents for colon cancer.
A tutorial in my laboratory would provide experience in molecular biology and biochemistry techniques involved in studying signal transduction pathways.
Program in Cancer Biology
Office: MDA T7.3891 (Unit 18-4)
Ph.D. - University of Illinois - 1981