Dr. Angabin Matin
The University of Texas MD Anderson Cancer Center
Department of Genetics
My laboratory studies the genetics of testicular germ cell tumor development in mice. Testicular germ cell tumors originate from primordial germ cells and develop within the testis during fetal development. These tumors resemble aspects of testicular cancer in humans. Identification of the genes involved in testicular germ cell tumor development in mice provides us with fascinating leads for understanding primordial germ cell biology as well as cancer development.
Testicular tumors occur spontaneously at an appreciable frequency in the 129 family of inbred strains of laboratory mice. Germ cell tumors in the 129 strain were the first tumor models where the tumor cell of origin (the primordial germ cell) and the time of cancerous transformation (during embryonic stages) were precisely defined. This makes them a very useful model system to study the factors that initiate testicular tumor development.
Evidence indicates that a large number of genes are responsible for germ cell tumor development. My laboratory is pursuing several approaches to identify genes involved in tumor development. Using chromosome substitution strains (CSS) and congenic strains, we have successfully mapped and identified a number of germ cell tumor causing genes from mouse Chromosome 19.
Another approach in the lab is based on analyzing single gene mutations that affect germ cell biology and tumor susceptibility. Using positional cloning approaches, we identified a gene from mouse Chromosome 18, called Dead end, whose inactivation increases incidence of testicular germ cell tumors. Sequence analysis of Dead end encoded protein indicates it is homologous to factors involved in gene editing. Work in my laboratory is geared towards unraveling the function of Dead end in primordial germ cells and in testicular cancer. These studies will help us better understand factors involved in the development of primordial germ cells as well as processes that result in germ cell tumor development.
Office: MDA BSRB S11.8116b (Unit 1006)
Title: Associate Professor
Ph.D. - The University of Texas Graduate School of Biomedical Sciences at Houston - 1993