Dr. Chengming Zhu
The University of Texas MD Anderson Cancer Center
Department of Immunology
- Mouse models for lymphocyte development
- Mechanism and regulation of programmed and general DNA recombination/repair
- Genomic stability
- Tumorigenesis in the lymphoid system
The research in my laboratory is directed at understanding the mechanism and regulation of general and programmed DNA repair and recombination, and role as a caretaker of genomic stability. A strong interest in our lab is in factors that participate in a unique DNA repair pathway termed non-homologous end-joining (NHEJ), and factors that involve the cell cycle control of this pathway, using lymphocyte development in normal and knockout mice as models. Current studies in our lab focus on analyzing and comparing different deficient mice that develop lymphomas of T or B lineage, and understanding the role of DNA breaks in inducing chromosomal abnormalities such as translocations and amplification, and its contribution to malignancy transformation.
Depending on the student's interests, a tutorial in my laboratory would provide experience with mouse genetics, basic immunological and molecular techniques, cytogenetics, and tissue culture, especially mouse ES cell experiences. My new research projects involve functional analyses of DNA ligases, by using mouse models and RNA interference approach. Students working on this project will gain experience in RNAi, western blotting, basic immunofluorescence technique, and other unique assays such as class switching recombination and somatic hypermutation in B lymphocytes.
Program in Immunology
Office: MDA SCR4.3019 (Unit 902)
Title: Associate Professor
Ph.D. - Baylor College of Medicine - 1997