Dr. Jian Kuang
The University of Texas MD Anderson Cancer Center
Department of Experimental Therapeutics
The central theme of my research is to understand the molecular mechanism that controls cell proliferation and transformation. One of the major components in the program is aimed at identifying crucial missing links in the regulatory system that control the G2/M transition in the eukaryotic cell cycle, including previously unrecognized kinases and phosphatases that regulate Cdc25 activation, enzymes that generate and eliminate the mitosis-specific epitope recognized by the monoclonal antibody MPM-2 and the non-Cdc2 components of maturation promoting factor activity.
The other focus of my research is to understand the functions and regulations of a multifunctional scaffold protein called Alix, which is critically involved in endosomal sorting, retroviral budding, cytokinesis, apoptosis, actin cytoskeleton assembly, cell adhesion and extracellular matrix assembly. Besides, we also study the functions and regulations of Alix-related protein HD-PTP for its malignancy-inhibitory role.
A tutorial in my laboratory would provide basic biochemistry, molecular biology and cell biology skills in using cultured mammalian cells to study cell proliferation and transformation.
Office: MDA 3SCR4.3420 (Unit 1950)
Title: Associate Professor
Ph.D. - The University of Texas Graduate School of Biomedical Sciences at Houston - 1990