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GS03 1012 Mass Spectrometry in Biomedicine

Zhou, Dapeng. Two semester hours. Summer. This course provides an introduction to mass spectrometry (MS) principles and most cutting edge MS instruments, as well as their application in fields of functional proteomics, glycomics and lipidomics.

Lectures focus on the theory of modem methods of ionization for biomolecules, instrumentation (4700 MALDI TOF/TOF Analyzer and LTQ-XL Linear Ion Trap MS), practical applications with specific examples, and the advantages and limitations of each method. Biological applications on functional proteomics, glycomics, and lipidomics will be presented, which will include connection of conventional biochemistry methods to MS methods, optimal MS methods and MS methods adapted to various chromatographic techniques.