CCTS Protocols

Active Protocols

Principal InvestigatorTitle
Ambrose, Catherine G. PhD Identification of causative bacteria in osteomyelitis using rapid and sensitive 16SrRNA detection
Arnett, Frank MD An immunogenetic database and storage bank for rheumatic and autoimmune diseases
Bell, Tanvir K. MD Evaluation of cardiovascular effects of smoking cessation in HIV infected patients
Brod, Staley A. MD Prevention of cognitive decline in Alzheimer's disease by ingested interferon alpha
Brod, Staley A. MD A Phase II/III, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Multi-Center Study to Evaluate the Safety and Efficacy of Rituximab (Mab Thera® /Rituxan® ) in Adults with Primary Progressive Multiple Sclerosis.
Brod, Staley A. MD Controlled high risk AVONEX (Interferon Beta-1a) multiple sclerosis prevention study in ongoing neurological surveillance (CHAMPIONS)
Brod, Staley A. MD Evaluation of plasma cortisol concentration after subcutaneous (S.C.) and intramuscular (I.M.) administration of H.P. Acthar® gel in healthy volunteers
Brod, Staley A. MD At risk for MS (Twin Study)
Brod, Staley A. MD Peripheral and central protein biomarkers of brain MR activity in demyelinating disease
Brown, Deborah L. MD Use of whole blood and cell-rich coagulation assays for the detection of non-overt DIC in sepsis
Brown, Deborah L. MD A phase II/III trial evaluating the safety, pharmacokinetic properties and efficacy of a plasma derived anti-thrombin III concentrate with administration in surgery, pregnancy and thromboembolic or thrombic events
Bull, Joan M.C. MD A phase II clinical trial of a timing/schedule optimizing combined-modality regimen: Cisplatin+ metronomic low-dose interferon (IFN-a) followed by Gemcitabine HCl (gemzar) in combination with mild, fever-range whole body hyperthermia (FR-WBH) in patients with advanced inoperable pancreatic cancer
Bull, Joan M.C. MD Phase II trial of mild WBH combined with liposomal doxorubicin/5-FU in patients with advanced malignancy
Bull, Joan M.C. MD Phase I-II clinical trial of cisplatin (Platinol) followed by gemcitabine HCl (Gemzar) in combination with mild, fever-range whole body hyperthermia (LL-WBH) at 40 c in patients with advanced malignancies
Busaidy, Kamal, MD Osteonecrosis risk assessment longitudinal (ORAL) study: Feasibility assessment
Cox Jr, Charles S. MD Safety of autologous stem cell treatment for traumatic brain injury in children
Crommett, John MD Vasopressin levels in patients with cervical spine injury and neurologic deficit
Escobar, Miguel MD Rituximab for the treatment of inhibitors in congenital hemophilia A- The RICH study
Estrada-Y-Martin, Rosa M. MD Correlation between salivary cortisol and total serum cortisol to free serum cortisol in MICU patients with septic shock
Evans, Patricia, MD Free parking for parents of extremely low birth weight infants: would there be important benefits to the baby?
Ferrendelli, James, MD A double-blind, placebo-controlled, parallel-group study of rufinamide given as adjunctive therapy in patients with refractory partial seizures
Frazier, Lorraine, DSN Multi-detector CT angiography (MDCTA) for previously undetected cardiac and non-cardiac pathology in asymptomatic high-risk individuals
Frost, Jeffrey PhD A retrospective analysis of NET1 genes in human breast cancer
Fuentes, Francisco MD Genetic Analysis for Arrhythmic Disorders
Fuentes, Francisco MD A multicenter, double-blind, randomized study to establish the clinical benefit and safety of Vytorin (Ezetimibe/Simvastatin Tablet) vs Simvastatin monotherapy in high-risk subjects presenting with acute coronary syndrome (Improved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE IT)
Fuentes, Francisco MD Future revascularization evaluation in patients with diabetes mellitus: optimal management of multivessel disease. FREEDOM trial
Fujise, Kenichi, MD Fortilin - a novel compound for predicting development of atherosclerosis
Gagliardi, Michael, MD A phase III, multicenter, placebo-controlled, randomized, double-blind study to evaluate the safety and efficacy of PAROCHYMAL (ex vivo cultured adult human mesenchymal stem cells) intravenous infusion for the induction of remission in subjects experiencing treatment-refractory moderate-to-severe Crohn's disease
Gambello, Michael J. MD PhD Genetic characterization of patients with autism
Guo, Dongchuan PhD Genomic polymorphisms and sporadic thoracic aortic aneurysms and dissections
Gupta, Monesha, MD; Portman, Ronald MD Assessment of cardiovascular structure and function in hypertensive and normotensive children and assessment of vascular function in hypertensive children
Hanis, Craig, PhD Family studies of type 2diabetes and impact of selected genes on development of type 2 diabetes in adults and adolescents in the Lower Rio Grande Valley
Hoelscher, Deanna PhD Training interventions and genetics of exercise response study-the TIGER study
Hoots, Keith MD The molecular and clinical biology of von Willebrand disease
Hoots, Keith MD Modifiers of clinical phenotype in patients with hemophilia
Jiang, Zhi-Dong PhD Study of single nucleotide polymorphism (SNP) presence or absence in genes including intestinal receptors for cytokines or enteric pathogens in patients who are susceptible or resistant to travelers' diarrhea
Katancik, James, DDS Monocyte tissue factor expression in diabetes mellitus
Kennedy, Kathleen MD, MPH Cross-over trial for medical treatment for GERD in preterm infants
Kennedy, Kathleen MD, MPH Management of hyponatremia in preterm infants on diuretics
Kleinerman, Eugenie S. MD Randomized phase II study of vincristine, doxorubicin, cyclophosphamide and desrazoxane (VACdxr) with or without ImmTher for newly diagnosed high risk Ewing's Sarcoma
Lavis, Victor R. MD Bypass angioplasty revascularization investigation 2 diabetes (BARI 2D)
Levine, Robert MD Proteomics of brain-trauma-associated elevated intracranial pressure (ICP)
Lindsey, J. William MD Open label study to evaluate the safety of Copaxone, and to monitor the neurologic course of disease of multiple sclerosis patients treated with Copaxone (Teva)
Lindsey, J. William MD Multicenter, double-blind, randomized study comparing the combined use of interferon beta-1a (Avonex) and glatiramer acetate (Copaxone) to either agent alone in patients with relapsing-remitting multiple sclerosis (CombiRx-Phase III)
Lindsey, J. William MD Acorda Protocol MSF03: Double-blind, placebo-controlled, 21-week, parallel group study to evaluate the safety and efficacy of oral fampridine-SR (10 mg BID) in subjects with multiple sclerosis
Lindsey, J. William MD The immune response to Epstein-Barr virus in multiple sclerosis (Normal Volunteers)
Lindsey, J. William MD The cellular immune response against Epstein-Barr virus in multiple sclerosis
Madjid, Mohammad MD Effect of statins on periodontal inflammation: a retrospective study
Mayes, Maureen D.MD, MPH The scleroderma family registry and DNA repository
Mayes, Maureen D.MD, MPH Long Term Bosentan Label Extension Of The RAPIDS-2 Study In Systemic Sclerosis Patients With Ischemic Digital Ulcers
Mayes, Maureen D.MD, MPH A randomized prospective Phase II/III multi-center study of high-dose immunosuppressive therapy using total body irradiation, cyclophosphamide and ATG with hematopoietic progenitor cells, apheresis CD34 enriched, for autologous use versus pulse intravenous cyclophosphamide for the treatment of severe systemic sclerosis
Mayes, Maureen D.MD, MPH Sociodemographic, behavioral and immunogenetic determinants of outcome in systemic sclerosis (SSc)
Mayes, Maureen D.MD, MPH An observational, long term, follow-up study of eligible individuals declining to participate in the scleroderma cyclophosphamide or transplantation (SCOT) study (SCOT Decliners Registry)
Mayes, Maureen D.MD, MPH Phase III open label study of a topical gel formulation of nitroglycerin, MQX-503 in the treatment and prevention of Raynaud's phenomenon
Mayes, Maureen D.MD, MPH Pilot study to examine the use of imatinib (Gleevec) for the treatment of active alveolitis in systemic sclerosis
McPherson, David, MD Flow mediated vasodilatation in sickle cell disease
Milewicz, Dianna M MD, PhD Ethnic differences in the genetic basis of intracranial aneurysms
Milewicz, Dianna M. MD, PhD Genetic basis of vascular disease/TexGen research project
Milewicz, Dianna M. MD, PhD Genetic basis of aortic aneurysms
Milewicz, Dianna, MD, PhD Genetic basis for vascular disease (HVM1 and HVM2)
Moeller, Frederick G. MD Serotonin, drug use, and MDMA induced deficits
Murray, Nancy DrPH HEADS UP to Teachers and Parents
Murthy, Jayasimha, MD Thermal imaging, a novel non-contact method to detect apnea/hypopnea during polysomnography
Navarro, Fernando, MD PILOT STUDY: The physiological basis for dietary protein intolerance in children with autism
Nelson, Flavia, MD A 24-month double-blind, randomized, multicenter, placebo-controlled, parallel-group study comparing efficacy and safety of fingolimod (FTY 720) 1.25 mg and 0.50 mg administered orally once daily versus placebo in patients with relapsing-remitting multiple sclerosis
Northrup, Hope MD Molecular Genetics of Neural Tube Defects
Okhuysen, Pablo C. MD Pathogenicity of enteroaggregative E.coli in adult volunteers
Okhuysen, Pablo C. MD Infectivity of Cryptosporidium parvum for adult humans
Okhuysen, Pablo C. MD A randomized, open label, phase III, international study of subcutaneous recombinant interleukin-2 (Proleukin) in patients with HIV-1 infection and CD4+ cell counts> 300/mm3: evaluation of subcutaneous Proleukin in a randomized international trial (ESPRIT)
Okhuysen, Pablo C. MD A randomized, open-label, international study of subcutaneous recombinant interleukin-2 (rIL-2, Aldesleukin) with and without concomitant antiretroviral therapy in patients with HIV-1 infection and CD4+ cell counts ≥300/mm³: study of Aldesleukin with and without antiretroviral therapy (ESPIRIT 002: STALWART)
Okhuysen, Pablo C. MD Seroepidemiologic study of enterotoxigenic Escherichia coli (ETEC) in US travelers to Mexico
Parikh, Nehal A., DO Structural brain abnormalities on volumetric MRI as a predictor of long-term neurosensory impairments in extremely low birth weight infants
Parikh, Nehal A., DO A randomized trial of hydrocortisone in very preterm infants at high risk for neurologic and pulmonary impairments
Parikh, Nehal A., DO Evaluation of diffusion tensor magnetic resonance imaging (DTI) as a predictor of neurosensory impairments in extremely preterm infants
Paul, Sudhir PhD The generation of a comprehensive universal autoimmune antibody library
Ramin, Susan R. MD A randomized clinical trial of treatment of mild gestational diabetes mellitus
Restrepo, Blanca PhD Altered expression of immune response genes in tuberculosis patients with diabetes
Reveille, John D. MD A multicenter, randomized, double-blind, placebo-controlled trial of Golimumab, a fully human anti-TNF-α monoclonal antibody, administered subcutaneously in subjects with active ankylosing spondylitis
Reveille, John D. MD A phase III, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of rituximab in subjects with ISN/RPS class III or IV lupus nephritis
Reveille, John D. MD Genetics of ankylosing spondylitis pathogenesis (Australian-Anglo-American Spondylitis Consortium) (TASC)
Reveille, John D. MD Defining the spectrum of spondyloarthritis in family members of patients with ankylosing spondylitis
Reveille, John D. MD Cognitive function in SLE (COGNITION)
Rhoads, Marc, MD Effect of lactobacillus reuteri on colic symptoms and excessive breath hydrogen in infants with colic
Robinson, Emily K. MD A randomized phase III study of conventional whole breast irradiation (WBI) versus partial breast irradiation (PBI) for women with stage 0, I, II breast cancer
Ruppe, Mary D MD Study of the endocrine regulators of phosphate homeostasis
Samuels, Joshua, MD, MPH (was Portman, Ronald MD) Chronic kidney disease in children study (CKiD)
Schiess, Mya MD A randomized, double-blind, active (pramipexole 0.5 mg tid) and placebo-controlled, efficacy study of pramipexole given 0.5 mg and 0.75 mg bid over a 12-week treatment phase in early Parkinson's disease patients
Sellin, Joseph, MD Impact of race and ethnicity on inflammatory bowel disease (IBD)
Sereno, Anne B. PhD Visual attention: Interactions and dissociations between reflexive and voluntary processes & neural substrates of attention and orienting
Slater, Jeremy, MD An international, double-blind, parallel-group, placebo-controlled, randomized study: evaluation of the efficacy and safety of brivaracetam in subjects 16 to 70 years old with partial onset seizures
Smalling, Richard MD PhD PATCAR Pilot Trial- Prehospital administration of thrombolytic therapy with urgent culprit artery revascularization
Smith, Judith A. PharmD Evaluation of the bioavailability of castor oil when administered orally vs intramuscularly vs as a vehicle for 17-α-hydroxyprogesterone in pregnant women
Swann, Alan MD Norepinephrine and impulsivity
Taegtmeyer, Heinrich MD, DPhil Glucolipotoxicity and cardiac dysfunction in obesity
Tan, Filemon K. MD, PhD Genetic and protein studies of fibrillin-1 in scleroderma
Thomas, Eric MD, MPH Improving teamwork for neonatal resuscitation
Van Horn, Gage, MD Evaluation of the Effectiveness of Subthalamic Deep Brain Stimulation and Its Effect on Neuropsychological Function in the Treatment of Medically Intractable Parkinson’s Disease
Van Horn, Gage, MD Prospective randomized investigation to evaluate incidence of headache reduction in subjects with migraine and PFO using the amplatzer PFO occluder compared to medical management. PREMIUM Trial
Xia, James J., MD, PhD Computer-aided surgical simulation for craniofacial surgery